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Korean Journal of Obstetrics & Gynecology 2002;45(8):1411-1415.
Published online August 1, 2002.
A Case Of Periventricular Leukomalacia Related To Chorioamnionitis.
Young Sun Ahn, Kyung Seo, Jong Hwa Kim, Sung Rok Park, Jong Seung Shin
Department of Obstetrics & Gynecology, Yonsei University, College of Medicine, Seoul, Korea.
Periventricular leukomalacia is a major cause of neuro-developmental delay in premature infant. Although it develops in only a small percentage of preterm infants, the condition poses a major problem. The pathogenesis of periventricular leukomalacia is not well established. Because of the topography of the lesion, a decreased cerebral perfusion occurred before delivery is thought to be a critical pathogenetic factor. Therefore, hypoxic brain damage is thought to be a major cause of periventricular leukomalacia. The importance of neurochemically mediated injury to the white matter has been stressed. Recently, high incidence of placental chorioamnionitis with periventricular leukomalacia. We experienced a case of periventricular leukomalacia related to chorioamnionitis. The pathology of placenta was chorioamniontis, and it was thought to be a cause of periventricular leukomalacia. So, we report our case with a short literature review to ensuring that chorioamionitis without perinatal asphyxia cause a periventricular leukomalacia.
Key Words: Periventricular leukomalacia, Chorioamnionitis, Perinatal asphyxia

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