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Korean Journal of Obstetrics & Gynecology 2002;45(6):1092-1096.
Published online June 1, 2002.
Hyperreactio luteinalis associated with a normal singleton pregnancy.
Kwang Beom Lee, Gwang Jun Kim, Byung Cheul Hwang, Hyun Yee Cho
1Department of Obstetrics and Gynecology, Gachon Medical School, Inchon, Korea.
2Department of Pathology, Gachon Medical School, Inchon, Korea.
Hyperreactio luteinalis is a rare disease characterized by marked cystic enlargement of the ovary due to multiple benign theca lutein cyst. The cause of this disease is not well known but is believed to be induced by high serum levels of human chorionic gonadotropins (hCG). It occurs usually in gestational trophoblastic disease, multiple pregnancies, and rarely in normal pregnancy. In nature, hyperreactio luteinalis is a benign condition. Therefore, the appropriate management is conservative, but surgical intervention is definitely indicated to remove infarcted tissue, control hemorrhage, or decrease androgen production in virilized patients. Here we report a case of hyperreactio luteinalis which was diagnosed at 11 weeks gestation. Lower abdominal pain was developed and progressed. Emergent right wedge oophorectomy and left salpingoophorectomy was performed due to probable torsion of left ovarian cyst and the pregnancy maintained. Theca lutein cysts were confirmed on pathologic examination.
Key Words: Hyperreactio luteinalis, hCG, Theca lutein cyst, Pregnancy

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