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Korean Journal of Obstetrics & Gynecology 2002;45(5):873-877.
Published online May 1, 2002.
A case of vaginal delivery in woman with congenital factor V deficiency.
Bok Ja Kim, Chang Hee Lee, Young Han Kim, Jae Sung Cho, Yong Won Park
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
Congenital factor V deficiency is a rare coagulation disorder, which is genetically autosomal recessive. In 1947, Owren first described a case of parahemophilia. During childhood, ecchymosis (bruising), epistaxis, oral hemorrhage, soft-tissue hemorrhage, and postpartum hemorrhage are noted in half of the patients. Because factor V is involved in common pathway in the coagulation scheme, prothrombin time (PT) and partial thromboplastin time (PTT) are prolonged. Definite diagnosis can be made with a specific factor V assay. Fresh frozen plasma would appear to be the treatment of choice. For the first time in Korea, we experienced a case of vaginal delivery in a patient with factor V deficiency. She delivered a male baby weighing 3120gm with median episiotomy. Six units of fresh frozen plasma were transfused during delivery. After additional transfusions of fresh frozen plasma, she was discharged on fourth postpartum day without hemorrhage or hematoma.
Key Words: factor V, congenital, deficiency, fresh frozen plasma, vaginal delivery


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