Korean J Obstet Gynecol Search


Korean Journal of Obstetrics & Gynecology 2002;45(2):285-291.
Published online February 1, 2002.
The Effects of Estrogen Replacement Therapy and Pamidronate on the Bone Metabolism of Postmenopausal Women.
Jae Oh Lee, Heung Yeol Kim
1Department of Obstetrics & Gynecology, Pohang Presbyterian Hospital, Pohang, Korea.
2Department of Obstetrics & Gynecology, School of Medicine, Kosin university, Pusan, Korea.
To evaluate the effects of estrogen replacement therapy and pamidronate on the bone metabolism in the postmenopausal women. METHODS: This prospective randomized clinical trial examined the effects of oral pamidronate and conjugated equine estrogen, in combination and seperately, on biochemical markers of bone turnover in 140 women with low bone mass. Treatment included pamidronate (group I, n=50), or conjugated equine estrogen (group II, n=50), conjugated equine estrogen plus alendronate (group III, n=40) for 12 months. Biochemical markers of bone turnover were also measured at months 6 and 12 months. RESULTS: Serum osteocalcin and urinary deoxypyridinoline in Group I, Group II and Group III decreased signifiantly at 12 months of treatment (p<0.05). But total alkaline phosphatase decreased significantly during the treatment in Group III, but not in Group I and Group II. CONCLUSION: The combined treatment with pamidronate and conjugated equine estrogen is more effective in postmenopausal women with osteoporosis by decreasing bone biochemical markers.
Key Words: Pamidronate, Estrogen, Bone biochemical markers, Postmenopause

Article category

Browse all articles >


Browse all articles >

Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea
Tel: +82-2-3445-2382    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2023 by Korean Society of Obstetrics and Gynecology.

Developed in M2PI

Close layer
prev next