Epithelioid trophoblastic tumor: A Case Report and Review of the Literature.

Oh, Hee Suk; Shin, Jung Ho; Song, Seung Hun; Chough, Soo Yong; Hur, Jun Young; Kim, Chul Hwan; Kim, Yuk Jae; Saw, Ho Suk

Case Report

Korean Journal of Obstetrics & Gynecology 2001;44(7):1330-1335.
Published online July 1, 2001.

Epithelioid trophoblastic tumor: A Case Report and Review of the Literature.

Hee Suk Oh, Jung Ho Shin, Seung Hun Song, Soo Yong Chough, Jun Young Hur, Chul Hwan Kim, Yuk Jae Kim, Ho Suk Saw

¹Departments of Obstetrics and Gynecology, Guro Hospital, College of medicine, Korea University, Seoul, Korea.
²Departments of Pathology, Guro Hospital, College of medicine, Korea University, Seoul, Korea.

Abstract

Epithelioid trophoblastic tumor (ETT) is an unusual variant of gestational trophoblastic tumor that is closely related to choriocarcinoma and placental site trophoblastic tumor (PSTT) but shows different morphologic, immunohistochemical features. ETT grows in a nodular pattern compared with the infiltrative pattern of PSTT. Histologically the tumor is characterized by uniform population of mononucleate intermediate trophoblastic cells that resemble the trophoblastic cells in the chorionic laeve, so we called them "chorionic-type intermediate trophoblast". Immunohistochemically ETT was positive for cytokeratin, epithelial membrane antigen(EMA) and staining for human placental lactogen (hPL) and human chorionic gonadotrophin (hCG) was generally patchy, focal or negative whereas PSTT contained more hPL-positive cells than hCG-positive cells. ETT can behave in a malignant fashion such as distant metastasis. We experienced a case of ETT by clinical result, pathologic finding, so we report a case with brief literature review.

Key Words: Epithelioid trophoblastic tumor, Placental site trophoblastic tumor