Juvenile Granulosa Cell Tumor of Ovary in a Premenarcheal Girl.

Park, Jong Hoon; Ahn, Ki Heon; Lee, Dong Hyung; Kim, Ki Hyung; Yoon, Man Soo

Original Article

Korean Journal of Obstetrics & Gynecology 2001;44(7):1324-1329.
Published online July 1, 2001.

Juvenile Granulosa Cell Tumor of Ovary in a Premenarcheal Girl.

Jong Hoon Park, Ki Heon Ahn, Dong Hyung Lee, Ki Hyung Kim, Man Soo Yoon

Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Pusan, Korea.

Abstract

Granulosa cell tumors are rare in children, and less than 5% of all cases occur before puberty. In premenarcheal girls, the juvenile type of this tumor usually elicits the signs of sexual precocity. We have recently experienced a case of juvenile granulosa cell tumor of the ovary presented with sexual precocity. It is different from the adult granulosa cell tumor with regard to clinical and pathological features as well as biological behaviour as previously described by Scully. Only the clinical stage at the time of diagnosis is considered to be related to the prognosis. About 90% are diagnosed in early stage with a favorable prognosis. More advanced stage have a poor clinical outcome.

Key Words: Juvenile granulosa cell tumor, Precocious pseudo-precocity