| The Concentration of Estradiol, Testosterone and Insulin-like Growth Factor-I in Follicular Fluid of Patients with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation. |
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Sung Hoon Kim, Hye Eun Kwon, Eun Ju Park, Hee Dong Chae, Chung Hoon Kim, Byung Moon Kang, Yoon Seok Chang |
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Division of Rep roductive Endocrinology and Inf ertility, Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. |
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| Abstract |
OBJECTIVE
To evaluate microenvironment of follicular fluid, such as estradiol(E2), testosterone(T), and insulin-like growth factor-I(IGF-I) of patients with polycystic ovary syndrome(PCOS) undergoing controlled ovarian hyperstimulation(COH) for in vitro fertilization and embryo transfer(IVF-ET). MATERIALS AND METHODS: From January 1996 to June 1998, follicular concentrations of E2, T, and IGF-I on the day of transvaginal ovum aspiration were measured in 40 patients undergoing COH for IVF-ET. The patients were grouped into the control(n=20) and the PCOS(n=20) groups. Statistical analysis was performed using Student's t-test, Fisher's exact test, and X2 test as appropriate. Statistical significance was defined as p<0.05. RESULTS: There were no significant differences in the follicular concentrations of E2, T, and IGF-I between the control and the PCOS groups. CONCLUSION: IGF-I might be not a main component of the local regulatory mechanisms involved in the pathogenesis of PCOS. |
| Key Words:
Polycystic ovarian syndrome, Follicular fluid, Insulin-like growth factor-I, Estrogen, Testosterone |
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