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Korean Journal of Obstetrics & Gynecology 1999;42(10):2182-2186.
Published online January 1, 2001.
The Effect of transdermal estrogen on pulsatility index of internal carotid artery in postmenopausal women - Effect of estrogen on arterial tone.
Sook Cho, Sei Ryun Kim, Woo Young Lee, Seung Kwon Kho, Seong Ook Hwang, Mi Young Kim
Abstract
OBJECTIVES
To evaluate the effect of transdermal estrogen on arterial tone. METHODS: In 30 postmenopausal women, doppler ultrasound was used to assess blood flow characteristics in internal carotid arteries. As the pulsatility index(PI) represents impedance to blood flow distal to the point of sampling, pulsatility index of internal carotid artery was measured from the flow velocity waveform. Patients were studied pretreatment and at weeks 8, 12, and 24 of treatment with transdermal estradiol 50microgram/day. RESULTS: Blood pressure was not changed during transdermal estrogen replacement therapy. Serum estradiol was increased from 13.4+/-13.7pg/ml to 55.8+/-32.8pg/ml with week 8 of treatment and it was maintained until week 24. The mean pulsatility index was fallen to 0.1+/-0.1 during week 8 of therapy and a significant reduction in PI was maintained until week 24(p=0.0001). CONCLUSION: We believe that transdermal estrogen replacement therapy affects on the arterial tone and prevents cardiovascular disease in postmenopausal women.
Key Words: Transdermal estrogen replacement therapy, Doppler ultrasound, Pulsatility index
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