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Korean Journal of Obstetrics & Gynecology 1999;42(9):2008-2012.
Published online January 1, 2001.
Clinical Characteristics of 53 Patients with Recurrent Cervical Cancer Showing Lung Metastasis.
Soon Hyunk Hwang, Lee Jae Kyu, Joo Heon Lee, Sang Young Ryu, Jong Hoon Kim, Byoung Gie Kim, Sang Yoon Park, Eui Don Lee, Kyung Hee Lee
Abstract
OBJECTIVE
Pulmonary metastasis from carcinoma of the uterine cervix is relatively rare, and their clinical outcomes are not still remain unknown. This study is to evaluate survival and prognostic factors in recurrent cervical cancer patients showing lung metastasis. METHODS: From Jan. 1993 to Dec. 1996, 53 recurrent cervical cancer patients showing lung metastasis, registered in Korea Cancer Center Hospital, were retrospectively evaluated with respect to their clinical characteristics, response rate to salvage therapy, survival and prognostic factors. RESULTS: Median age of patients at recurrence was 58 years, and median interval of initial diagnosis to recurrence was 17 months. The most common histologic type was squamous cell carcinoma(82%), followed by adenocarcinoma(6%), adenosquamous(6%), and others(6%). Response rate to salvage therapy was 47%(complete response rate 23.5%, partial response rate 23.5%), and median survival was 10 months(range 1-39). 3 year survival rate was 18%. Age, initial stage, initial tumor size, interval of recurrence and type of chemotherapeutic regimen were not significant prognostic factors, but squamous cell carcinoma antigen(SCC) level at recurrence and response to salvage therapy was significant(p=0.0087, p=0.0104). CONCLUSION: Survival of recurrent cervical cancer patients with lung metastasis was poor despite salvage therapy. Those patients who showed low SCC level at recurrence and good response to salvage therapy had favorable outcomes.
Key Words: Recurrent cervical cancer, Pulmonary metastasis, Prognosis


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