The Effect of Tibolone on Bone Mineral Density in Postmenopausal Women with Osteopenia or Osteoporosis.

Park, J W; Shin, G C; Hur, E J

Randomized Controlled Trial

Korean Journal of Obstetrics & Gynecology 1999;42(6):1324-1327.
Published online January 1, 2001.

The Effect of Tibolone on Bone Mineral Density in Postmenopausal Women with Osteopenia or Osteoporosis.

Abstract

OBJECTIVE
The aim of the study is to assess the effect of 1 year of treatment with tibolone on bone mineral density [BMD] in postmenopausal women with osteopenia or osteoporosis. METHODS: Fifty postmenopausal women with osteopenia or osteoporosis entered a 1 year randomized study of treatment with tibolone 2.5mg/day. BMD of lumbar spine [L2-L4] was assessed by dual energy absorptiometry at baseline, 6 months, and 12 months. Serum FSH and E2 level were also assessed at baseline and 12 months. RESULTS: BMD at the studied site after 12 months of tibolone [0.81+/-0.09 g/cm2] was significantly higher as compared to baseline [0.76+/-0.09 g/cm2]. The gain of BMD was 6.6% [p<0.05]. Serum FSH and E2 values were remained stable as compared to baseline. CONCLUSION: This study suggests that tibolone treatment in postmenopausal women with osteopenia or osteoposis is effective.

Key Words: Tibolone, BMD, postmenopausal women, osteoporosis, osteopenia