| Efficacy of Simplified Protocols in IVF-ET with Highly Purified FSH[FSH-HP] for Ovulation Induction. |
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C H Lee, K J Hwang, J H Yoo, H C Kwon, K H Jang, J Y Kim, K S Oh |
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| Abstract |
OBJECTIVES
To compare simplified ovulation induction employing FSH-HP with that of simplified ovulation induction employing other pharmacologic agents with regard to ovulation induction characteristics, oocyte and embryo development, and pregnancy outcome. METHODS: From December 1, 1994 to August 31, 1997, those cycles who underwent in vitro fertilization and embryo transfer with FSH-HMG [84 cycles], GnRH agonist short protocol [142 cyclse] and long protocol [175 cycles] and FSH-HP [103 cycles], totalling 504 cycles. RESULTS: The duration of ovulation induction with FSH-HP was 7.6+/-0.2 days, which was significantly shorter than the 9.0+/-0.1 days when GnRH agonist was used, and the total dose of agents were also significantly less [26.4+/-1.1 ampules vs 34.8+/-1.2 ampules]. The incidence of premature luteinization, cycle cancellation rate, and OHSS development was similar between the two groups. In the FSH-HP group good endometrial response was observed. The serum estradiol concentrations were significantly lower than the GnRH agonist short and long protocols [p<0.05], but there was normal oocyte and embryo development. Rather, although there was no statistical significanse, the implantation rate was relatively higher whereas the abortion rate was relatively lower, leading to higher ongoing pregnancy rate overall. CONCLUSION: Ovulation induction with FSH-HP enables subcutaneous drug administration by the patient herself, therefore simplifying as much as possible the in vitro fertilization and embryo transfer process and affording conveniency for both the patient and the hospital. It is therefore suggested that simplified protocols in IVF-ET with highly purified FSH [FSH-HP] for ovulation induction is an efficient alternative to current standard protocols. |
| Key Words:
highly purified FSH[FSH-HP], simplified protocol, pregnancy outcome |
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