Korean J Obstet Gynecol Search

CLOSE


Korean Journal of Obstetrics & Gynecology 1999;42(3):622-624.
Published online January 1, 2001.
A Case of HAIR - AN Syndrome.
Sook Hwan Lee, Tae Ki Yoon, Kwang Yul Cha, In Pyung Kwak, Yoon Sung Nam
Abstract
Polycystic ovary disease is a heterogenous endocrinopathy with many interacting causal factors. One potential such factor is chronic hyperinsulinemia. multiple, independent lines of evidence suppart the contention that chronic hyperinsulinemia causes ovarian hyperandragenism. This evidence includes: (1) mutations in the insulin receptor gene that cause severe hyperinsulinemia appear to be associated with ovarian hyperandrogenism, (2) insulin stimulates ovarian thecal and sttomal androgen seaetion in vitro, and (3) in some experimental models, manipulation of circulating insulin concentrations results in changes in circulating androgens. Although the association between hyperinsulinemia and hyperandrogenism remains to be fully explained at the molecular level, chronic hyperinsulinemia appears to be an important cause of hyperandrogenism. We have experienced a case of HAIR AN syndrome showing hyperandrogenism, insulin resistance and acanthosis nigricans in infertile patient. So we report this case with a brief review of literatures.
Key Words: Hyperandrogenism, Insulin resistance, Acanthasis nigricans


ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
POLICY
FOR CONTRIBUTORS
Editorial Office
49-2 Chungmu-ro, Jung-gu, Seoul 04550, Korea
Tel: +82-2-2266-7238    Fax: +82-2-2277-5194    E-mail: journal@ogscience.org                

Copyright © 2023 by Korean Society of Obstetrics and Gynecology.

Developed in M2PI

Close layer
prev next