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Korean Journal of Obstetrics & Gynecology 1999;42(1):179-183.
Published online January 1, 2001.
Sertoli Cell Adenomas in Complete Testicular Feminization Syndrome.
Min A Kang, Jong Ho Kim, Suck Chul Choi, Hoe Saeng Yang, Jae Chul Sim, Jung Ran Kim
Abstract
Testicular feminization is an uncommon genetic disorder with considerably familial predisposition and results in total feminization due to end-organ unresponsiveness to androgens. It is characterized by the presence of testes in phenotypically female with adequate breast development, normal extemal genitalia, absence of mullerian structures, and meager or absence of body hair. These patients characteristically have male karyotype(XY) and negative sex chromatin and are at increased risk of undergoing malignant transformation of the undescended gonad. In recent times, the malignant potential of the dysgenetic gonads in the intersex patients with a Y chromosome has been stressed by many authors, but few reports of an association between testicular feminization syndrome and benign tumors such as Sertoli cell adenomas. In the present study, postoperative pathology revealed that the gonads were Sertoli cell adenomas. The main features of clinical presentation and histological studies are briefly discussed with a review of the literature.
Key Words: Complete testicular feminization syndrome, Sertoli cell adenomas


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