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Korean Journal of Obstetrics & Gynecology 1998;41(11):2771-2775.
Published online January 1, 2001.
Apoptotic Change in Placenta of Pregnancy-induced Hypertension.
Yeun Hae Lee, Byung Suk Lee, Yong Hee Lee, Hyung Min Choi, Yong Gyun Yoo, Jae Sung Cho, Ji Won Yi, Hae Kyung Kwon, Woo Ik Yang, Yong Won Park
Abstract
The mechanism of apoptosis was first discovered at the end of the 19th century, but it was only recently that its importance was recognized. Not only in a pathologic environment but also in a normal environment, apoptosis has an important role in homeostasis. The number of cells is restricted by apoptosis which is controlled by several SlgBS lll VlVO. In pregnancy, the placenta regulates the maternal-fetal exchange of molecules and functions as a barrier for the protection of the fetus. As the pregnancy proceeds, changes occur in the number and components of placental cells. Observing the placental tissues, apoptosis was found in the syncytiotrophoblasts of early and late pregnancy. In particular, the fact that apoptosis observed in the placenta of late pregnancy supports the hypothesis that pmgrammed cell death is a normal sequence. Pregnancy-induced hypertension is usually accompanied by abnormal placenta and intrauterine growth restriction. In this study, using the TdT-FragEL DNA fragmentation detection kit, the changes in the nucleus by apoptosis in the placental tissues of 23 to 40 gestational weeks in preeclampsia and eclampsia were compared with normal placenta. Apoptosis was observed in the normal term placenta and in pregnancy-induced hypertension patients, regardless of whether vasculopathy was observed in Doppler ultrasound or confirmed by pathology, more apoptoses were observed aside from the number of gestational weeks.
Key Words: Apoptosis, Placenta, Pregnancy induced hypertension


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