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Korean Journal of Obstetrics & Gynecology 1998;41(9):2483-2487.
Published online January 1, 2001.
A Case of M llerian Adenosarcoma of the Uterus with Sarcomatous Overgrowth.
J W Han, C H Chung, D H Jung, S H Park, W K Kim, G B Lee, K T Kim, H C Kim
Abstract
M llerian adenosarcoma has been described as a destinctive biphasic uterine tumor with benign neoplastic glands within sarcomatous stroma. It is a rare variants of mixed mesodermal tumors and considered to be a tumor of low grade malignancy with relatively good prognosis. The other histopathological variant of adenosarcoma is adenosarcoma with overgrowth by high-grade sarcoma. Sarcomatous overgrowth is seen in approximately 10% of adenosarcoma. The definition of sarcomatous overgrowth is the presence of a pure sarcoma, usually but not necessary of a higher grade and mitotic rate, that overgrows a typical adenosarcoma and accounts for at least 25% of the total tumor volume. In contrast to typical m llerian adenosarcoma of the uterus, ademosarcoma with sarcomatous overgrowth is extremely aggressive tumor frequently associated with metastasis, postoperative recurrence, rapid progression and death. For adequate management of patient, it is important to evaluate the presence or absence of the sarcomatous overgrowth when the m llerian adenosarcoma is diagnosed. Recently, we experienced a case of m llerian adenosarcoma with sarcomatous overgrowth in a 36-year-old married, nulliparous woman and report this case with a brief review of the literature.
Key Words: M llerian adenosarcoma, Sarcomatous overgrowth


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