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Korean Journal of Obstetrics & Gynecology 1998;41(4):1179-1183.
Published online January 1, 2001.
Tumor Angiogenesis as a Predictor of Recurrence in Stage I b and IIa Squamous Cell Carcinoma of the Uterine Cervix.
K W Lee, N W Lee, B W Yeom, B S Koo
Tumor growth and metastasis depend on the angiogenic activity involving both tumor and host cells. In 1991, Weidner et al following the work of Srivastava et al on melanoma, demonstrated that tumor microvessel density and microvessel count are a direct measure of tumor-host angiogenic activity and they porvide prognostic information regarding metastasis in patients with carcinoma of the breast, independant of other prognstic factors. The prresnt study was carried out to explore the possibility of using histologic microvessel count of sections from the tumor to predict recurrence of stage Ib and IIa squamous cell carcinoma of the cernix. Paraffin embedded tumor sections from 24 patients (12 patients free of disease after 3 years and 12 patients with recurrence) were stained immunohistochemically for factor VIII-related antigens. Vessel counting in the most active area of angiogenesis was performed by pathologist on a x200 microscopic field without knowledge of the patients` outcome. To predict recurrence, vessel count was compared with age, tumor size, lymphatic spread, lymph-vascular invasion. Only high microvessel count (mean 61.0, range 24~92, versus mean 30.8, range 24~44; P< .05) and tumor size (mean 3.83 cm, range 0~6, versus 1.3 cm, range 0~4; P< .05) were independent factors predicting recurrence. This study suggests that high microvessel count in tumors may be used to predict recurrence in stage Ib and IIa squamous cell carcinoma of the cervix.
Key Words: Angiogenesis, Squamous cell carcinoma, Factor VIII

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