The Effect of Hormone Replacement Therapy on Biochemical Markers of Bone Turnover in Postmenopausal Women.

Jeong, H K; Lee, S M; Lee, H H; Lee, I S; Lee, K H; Cho, T H

Original Article

Korean Journal of Obstetrics & Gynecology 1998;41(3):764-769.
Published online January 1, 2001.

The Effect of Hormone Replacement Therapy on Biochemical Markers of Bone Turnover in Postmenopausal Women.

H K Jeong, S M Lee, H H Lee, I S Lee, K H Lee, T H Cho

Abstract

The purposes of this study were to evaluate the effect of hormone replacement therapy on the bone mineral density and bone metabolism. Thirty-four postmeonpausal women, who visited Soonchunhyang University Hospital were assessed. After baseline study, conjugated equine estrogen [CEE, 0.625 mg, day 1~30] plus medroxyprogesterone acetate [MPA, 5 mg, day 1~12] were given for 12 months. The levels of serum osteocalcin, serum total alkaline phosphatase and urine deoxypyridinoline decreased significantly[p<0.05] after 12 months of hormone replacement therapy. Bone mineral density of Ward`s triangle of femur increased significantly[p<0.05] compared to basal level and 12months of hormone replacement therapy. These data suggest that hormone replacement therapy has effect of inhibiting bone turnover rate and increasing bone mineral density of Ward`s triangle of femur in postmenopausal women.

Key Words: Conjugate equine estrogen, Osteocalcin, Urine deoxypyridinoline, Bone mineral density