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Korean Journal of Obstetrics & Gynecology 1997;40(11):2482-2491.
Published online January 1, 2001.
c-erb B2 and p53 Overexpression in Presence of Human Papilloma Virus Type 16/18 Infection in Carcinomas of the Uterine Cervix: Genesis and Clinicopathologic Analysis.
Sang Min Lee, Cheon Jun Lee, Won Gue Kim, Un Dong Park, Man Ha Huh, Bang Hur, Moo Youn Cho, In Cheol Jeong
1Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Pusan, Korea.
2Department of Pathology, College of Medicine, Kosin University, Pusan, Korea.
3Department of Biochemistry, College of Medicine, Kosin University, Pusan, Korea.
Abstract
The 43 cases of the primary uterine cervical carcinoma were analyzed for HPV type 16/18 infection and also analyzed for overexpression of p53 and c-erb B2 oncoprotein to evaluate theirs oncogenic and clinicopathologic relationships. HPV type 16/18 infection was examined by polymerase chain reaction(PCR) and the overexpression of p53 and c-erb B2 protein by using immunohistochemical method. The results were as follow: 1. The HPV infection rate in primary uterine cervical carcinomas was 83.7% respectively.The standard clinicopathologic characteristics(age, histologic type, koilocytosis, mitosis, clinical stage, tumor size, cervical invasion depth, lymph node metastasis, parametrial invasion) were nat significantly correlated with HPV type 16/18 infectivity. 2. The overexpression rate of p53 protein was 72.1% and there was no Significant correlation between expression of p53 protein and the Clinicopathologic characteristics. 3. The overexpression of c-erb B2 oncoprotein was 44.2% and there was no significant correlation between the overexpression of c-erb B2 oncoprotein and the clinicopathologic characteristics. 4. There was no significant correlation between HPV type 16/18 infection and overexpression of p53 and c-erb B2 oncoprotein.
Key Words: c-erb B2, p53, Human papilloma virus, Carcinomas of the uterine cervix


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