Midtrimester Amniocentesis-Cytogenetic Analysis of 1,274 Cases.

Kwak, In Pyung; Kim, Nam Keun; Park, Sang Hee; Hong, Min Jung; Lim, Eun Hye; Kye, Jung Ung; Lee, Sook Hwan; Cha, Kwnag Yul

Original Article

Korean Journal of Obstetrics & Gynecology 1997;40(9):2021-2026.
Published online January 1, 2001.

Midtrimester Amniocentesis-Cytogenetic Analysis of 1,274 Cases.

In Pyung Kwak, Nam Keun Kim, Sang Hee Park, Min Jung Hong, Eun Hye Lim, Jung Ung Kye, Sook Hwan Lee, Kwnag Yul Cha

¹College of Medicine, Pochon CHA University, Korea.
²Department of Obstetrics and Gynecology, CHA General Hospital, Seoul, Korea.
³Human Genetics Center, CHA General Hospital, Seoul, Korea.

Abstract

Diagnostic amniocentesis is one of the most useful technique for the prenatal detection of genetic disorders. Traditionally standard amniocentesis has been most commonly performed during the 2nd trimester from 16 to 20 weeks` gestation. Our laboratory has received 1,284 midtrimester amniotic fluid specimens during the past 5 year period for cytogenetic analysis and 1,274 were successfully cultured and yielded results. This study was based on data from 1,274 genetic amniocentesis performed at CHA General Hospital from Jan. 1991 to Dec. 1995. Chromosomal abnormalities were found in 61(4.8%) of the cases. There were 23 cases of aneuploidy, 37 cases of chromosomal rearrangemen t and 1 case of mosaicism.

Key Words: Amniocentesis, Chromosome abnormality, Prenatal diagnosis