Korean J Obstet Gynecol Search


Obstet Gynecol Sci > Volume 55(9); 2012 > Article
Korean Journal of Obstetrics & Gynecology 2012;55(9):629-635.
DOI: https://doi.org/10.5468/KJOG.2012.55.9.629    Published online September 17, 2012.
Clostridium botulinum toxin A significantly inhibits uterine contractions in rats undergoing mifepristone-induced preterm labor.
Hang Yong Jang, Kyung Mi Lee, Young Sin Park, Myung Jin Moon, Won Bo Hahn, Eun Hee Ahn
Department of Obstetrics and Gynecology, Bundang CHA General Hospital, CHA University College of Medicine, Seongnam, Korea. bestob@cha.ac.kr
We investigated the in vivo tocolytic effect of Clostridium botulinum toxin A (BoNT/A) on mifepristone-induced preterm labor in rats. METHODS: On day 17 of gestation, an incision was made to expose the uterus, and BoNT/A (normal saline or 20 units) was injected into the uterine horns. On day 18, mifepristone was used to induce uterine contractions. Electrical activity of uterine contractions was measured via electromyography on day 19. RESULTS: In rats treated with 20 units of BoNT/A, the amplitude of uterine contractions was significantly decreased by 45.2 +/- 18.4 (P<0.05) from baseline, respectively. The total duration of uterine contractions was significantly decreased by 51.7 +/- 7.9 (P<0.01), respectively. The frequency of contraction bursts after treatment with 20 units of BoNT/A was decreased by 5.6 +/- 16.3 from the baseline (P=0.4). CONCLUSION: In rats undergoing mifepristone-induced preterm labor, BoNT/A significantly inhibited uterine contractility. The decrease in uterine activity was mainly caused by a decline in the duration and intensity rather than frequency of uterine contractions.
Key Words: Clostridium botulinum toxin A, Tocolytics, Preterm labor, Mifepristone, Rat
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 0 Crossref
  • 226 View
  • 0 Download
Related articles in Obstet Gynecol Sci

Article category

Browse all articles >


Browse all articles >

Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea
Tel: +82-2-3445-2382    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2020 by Korean Society of Obstetrics and Gynecology. All rights reserved.

Developed in M2community

Close layer
prev next