Clinical significance of Urinary Epidermal Growth Factor in Gynecologic Tumors.

Yoo, Keun Jae; Lee, Won Wook; Lee, Sung Ki; Kim, Jong Seok; Choi, Bum Chae; Kim, Soo Nyung

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Original Article

Korean Journal of Obstetrics & Gynecology 1997;40(4):872-878.
Published online January 1, 2001.

Clinical significance of Urinary Epidermal Growth Factor in Gynecologic Tumors.

Keun Jae Yoo, Won Wook Lee, Sung Ki Lee, Jong Seok Kim, Bum Chae Choi, Soo Nyung Kim

¹Department of Obsterics and Gynecology, konkuk University Colloge of Medicine, Seoul, Korea.
²Department of Obsterics and Gynecology, sumsung cheil hospital, Korea.

Abstract

OBJECTIVES
The purpose of this study was to get the clinical significance of urinary ocncentration of epidermal growth factor (EGF) of the patients with benign and malignant gynecologic tumors comparked to normal conterol group. METHODS: We studied the urinary EGF levels in 73 patients with gynecologic tumors at MIn-joong General Hospital of konkuk univ. the colleted samples were treated by radioimmnunoassay thechnique. chi-square analysis and STudent's t-test were used. significance was determined at the level of p < 0.05. RESULT: in 73 cases, benign gynecologic tumors were 54cases and gynecologic cancer were 19case (cervical cancer 8, ovarian cancer 8, other gynecologic cancer 3). the old in gynecologic cancers. The mean urinary EGF levels of the patients with benign gynlogic cancers. The mean urinary EGF levels of the patients with bengin gynecologic tumors was 16.4 +/- 6.6ng/mg. creatinie, and 16.1 +/- 4.7ng/mg. creatinine in gynecologic cancers (15.3 +/- 4.3ng/mg. creatinine in cervical cancer, 16.4 +/- 3.7ng/mg. cretinine in ovarian cancer), 16.7 +/- 3.7ng/mg. creatinine in normal control grop. There was no sinificant difference in urinary EGF levels between control group and the patients with gynecologic tumors. There was no significant difference in urinary EGF levels between benign gynecologic tumors and gynecologic cancers. CONCLUSION: Our data suggest that urinary EGF may not be useful as a marker of gynecologic turmor.

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