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Obstet Gynecol Sci > Volume 55(3); 2012 > Article
Korean Journal of Obstetrics & Gynecology 2012;55(3):192-196.
DOI: https://doi.org/10.5468/KJOG.2012.55.3.192    Published online March 1, 2012.
A case of clear cell adenocarcinoma in the uterine cervix of 52-year-old virgin.
Young Lan Lee, Kylie Hae Jin Chang, Min Sun Kyung, Hong Bae Kim, Sung Ho Park
Department of Obstetrics and Gynecology, Hallym University College of Medicine, Seoul, Korea. vth2000@naver.com
Clear cell adenocarcinoma (CCAC) of uterine cervix is very rare tumor and only 4%-9% of entire adenocarcinoma appears to be diagnosed as clear cell type. Risk factors and pathogenesis of this disease are not exactly revealed. The intrauterine exposure to diethylstilbestrol (DES) and associated non-steroidal estrogen during pregnancy before 18 weeks is the only known risk factor, and also hormonal changes or genetic causes are suggested as the risk factors. We report a case of CCAC in the uterine cervix of 52-year-old virgin who had never been exposed to DES, with a brief review of related literature.
Key Words: Clear cell adenocarcinoma, Diethylstilbestrol, Virgin

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