A giant endometrial polyp with tamoxifen therapy in postmenopausal woman.

Moon, Soo Hyeon; Lee, Seong Eui; Jung, In Kook; Jeong, Ju Eun; Park, Won Young; Yi, Woo Hee; Suh, Dong Soo; Yoon, Man Soo; Kim, Ki Hyung

doi:2011.54.12.836

Obstet Gynecol Sci > Volume 54(12); 2011 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2011;54(12):836-840.
DOI: https://doi.org/10.5468/KJOG.2011.54.12.836 Published online December 1, 2011.

A giant endometrial polyp with tamoxifen therapy in postmenopausal woman.

Soo Hyeon Moon, Seong Eui Lee, In Kook Jung, Ju Eun Jeong, Won Young Park, Woo Hee Yi, Dong Soo Suh, Man Soo Yoon, Ki Hyung Kim

¹Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Korea. ghkim@pusan.ac.kr
²Department of Pathology, Pusan National University School of Medicine, Busan, Korea.
³Department of Obstetrics and Gynecology, Busan St. Mary's Medical Center, Busan, Korea.

Abstract

Tamoxifen is a synthetic non-steroid anti-estrogen that has been used effectively for several years in the adjuvant treatment of breast cancer. But, the drug has been associated with development of endometrial poylp, hyperplasia and adenocarcinoma possibly mediated through its agonistic estrogen properties during the menopausal period in which estrogens are at a low level. Endometrial polyp has been described as the most common endometrial pathology in association with postmenopausal tamoxifen treatment. We present the case of woman with a giant endometrial polyp of uncommon dimension who was receiving adjuvant tamoxifen for 5 years after breast cancer surgery.

Key Words: Tamoxifen, Polyp, Breast neoplasm