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Obstet Gynecol Sci > Volume 67(3); 2024 > Article
Matemanosak, Peeyananjarassri, Klangsin, Wattanakumtornkul, Dhanaworavibul, Choksuchat, and Getpook: Clinical features and management of women with Mayer-Rokitansky-Küster-Hauser syndrome in a Thai population

Abstract

Objective

This study aimed to describe the clinical features, associated extragenital anomalies, and management of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome in a Thai population.

Methods

This retrospective study analyzed the medical records of 96 patients with MRKH syndrome diagnosed and treated at a university hospital and tertiary referral center in southern Thailand between 2000 and 2022.

Results

The study included 96 patients with MRKH syndrome. The most common symptom was primary amenorrhea (88.5%), followed by difficulty or inability to engage in sexual intercourse (9.4%) and pelvic mass (2.1%). Notably, 80.3% of the patients did not have extragenital malformations and were diagnosed with MRKH type I (typical form), whereas 19.7% were categorized as MRKH type II (atypical form). Skeletal malformations were the most frequent extragenital anomalies and were present in 19.5% of patients, with scoliosis being the most common skeletal condition. Other extragenital malformations included renal (8.5%) and neurological (1.0%) abnormalities. Clinical vaginal examination revealed complete atresia in 21.8% and vaginal hypoplasia (median vaginal length, 3 cm) in 78.2% of the patients. Half of the patients did not receive treatment because they had not engaged in sexual intercourse. In this cohort, 41.7% of the patients had no difficulty performing sexual intercourse. Hence, self-dilation therapy or concomitant dilation was recommended. Only eight patients (8.3%) underwent surgical reconstruction of the vagina.

Conclusion

This study confirmed the complexity and heterogeneity of the phenotypic manifestations of MRKH, including the degree of vaginal atresia and types and rates of associated malformations.

Introduction

Müllerian agenesis, also known as Mayer-Rokitansky-Küster-Hauser syndrome (MRKH), is a congenital disorder characterized by agenesis/aplasia of the Müllerian ducts during fetal development. MRKH syndrome is generally asymptomatic and is often diagnosed after puberty when the patient presents with primary amenorrhea, an inability to perform sexual intercourse, or dyspareunia. Women with MRKH syndrome typically exhibit the 46, XX karyotype. The external genitalia appear normal. However, the vagina is short, blind-ended, and may appear as dimples below the urethra. A uterine remnant may be present, with or without an endometrial cavity. Ovaries are typically normal in structure and function given their separate embryologic origins. Therefore, secondary sexual characteristics develop normally [1]. MRKH syndrome is a rare disorder with an estimated prevalence of 1:5,000 in women [2]. Despite its rarity, MRKH syndrome is the second most common cause of primary amenorrhea, following ovarian failure [3]. MRKH can be classified as type I (isolated) or type II (associated with malformations of extragenital organs involving the kidneys and skeleton) [2,4-6].
The initial evaluation of an adolescent with primary amenorrhea includes a physical examination, measurement of estradiol and follicle-stimulating hormone levels to assess ovarian function, chromosomal analysis to confirm a normal female karyotype, and imaging to assess the presence of the uterus [7]. Ultrasonography (USG) is the preferred initial diagnostic modality because it is simple and noninvasive [1]. Rudimentary Müllerian structures are found in 90% of patients with Müllerian agenesis on magnetic resonance imaging (MRI). Furthermore, MRI permits simultaneous evaluation of other associated anomalies, especially those of the urinary tract and skeletal system. Moreover, MRI can be used to assess the presence of endometrial activity within the Müllerian structures [8]. Laparoscopy is rarely indicated for diagnostic purposes and should be reserved for surgical interventions such as uterine remnant excision [1].
The management of Müllerian agenesis includes evaluation of associated congenital anomalies, interventions to improve vaginal length, and psychosocial counseling [7]. Müllerian agenesis negatively impacts sexual and psychological health. Women with this disorder may have lower self-esteem due to their inability to conceive as well as their inability to perform sexual intercourse [9,10].
The clinical presentation and extragenital organ malformations in MRKH syndrome differ among previous epidemiological studies from European countries and China [6,11-17]. Reports from Western countries and China have demonstrated heterogeneity in the phenotypic manifestations, including the types and rates of associated malformations, suggesting substantial ethnic differences. This study aimed to describe the clinical presentation, diagnosis, spectrum of associated congenital malformations, and management of Müllerian agenesis in a Thai population.

Materials and methods

This study was approved by the Institutional Review Board of the Faculty of Medicine at Songklanagarind Hospital (Institutional Review Board number: REC. 65-367-12-1). The database of all patients diagnosed with Müllerian agenesis between January 1, 2000 and October 31, 2022, was retrieved from the hospital information system of Songklanagarind Hospital, a tertiary referral center in southern Thailand. All medical records were reviewed and patients whose medical records could not be obtained were excluded from the analysis.

1. Identification of patients with Müllerian agenesis

We identified women with Müllerian agenesis by reviewing the medical records of patients with the following International Classification of Diseases 10th Revision diagnosis codes: N91, amenorrhea; N91.0, primary amenorrhea; N91.2, amenorrhea, unspecified; Q51.0, agenesis, and aplasia of the uterus; Q51.5, agenesis, and aplasia of the cervix; Q51.8, other congenital malformations of the uterus and cervix; and Q52.0, congenital absence of the vagina.
The definitive diagnosis of Müllerian agenesis was retrospectively reviewed by consensus between two experienced reproductive endocrinologists based on the presence of the following features: primary amenorrhea with uterine agenesis/aplasia, normal profile of reproductive hormones or normal secondary sexual characteristics, and normal female karyotype (46, XX). Patients with no available karyotype data or those with the 46, XY karyotype were excluded from the analysis (Fig. 1).
Routinely performed diagnostic procedures included a thorough gynecological examination, pelvic USG, MRI, conventional karyotyping, and hormonal tests, including follicle-stimulating hormone and estradiol. Serum total testosterone levels were investigated solely in patients with hyperandrogenic symptoms. Associated extragenital anomalies involving the kidneys were evaluated using renal USG, intravenous pyelography, and MRI. Spinal abnormalities were identified using plain radiography or MRI. Patients with suspected cardiac or neuronal malformations were further examined by echocardiography, audiometry, or imaging-based tests. Organ malformations were classified according to the vagina cervix uterus adnex-associated malformation (VCUAM) classification.

2. Statistical analysis

All data were presented as frequency and percentages using SPSS Statistics software (IBM Corp., Armonk, NY, USA).

Results

The medical records of 102 patients with MRKH syndrome who were diagnosed and treated during the study period were reviewed. Six patients were excluded due to missing karyotype results. The characteristics of the 96 patients are summarized in Table 1. The median patient age at diagnosis was 21 years. Only six patients (6.5%) were diagnosed before 15 years of age. The most common symptom was primary amenorrhea (88.5%), followed by difficulty or inability to engage in sexual intercourse (9.4%), and the presence of a pelvic mass (2.1%).
Pelvic examinations were not performed in 18 patients (18.8%) because they had never experienced sexual intercourse. More than half of the patients (52.0%) had undergone hormonal investigations, and all of these revealed normal estrogen levels (median of 72.6, interquartile range 51.7-220.9 pg/mL). All the remaining patients with no hormonal results had normal secondary sexual characteristics. The majority of patients were investigated for the presence of a uterus via transabdominal USG (83.3%), followed by transvaginal USG (16.7%), and both ultrasonography methods (5.2%). MRI was performed in 37.5% of the patients. Karyotype analysis was performed in all patients and revealed a normal karyotype of 46, XX, except for one patient whose karyotype test showed 46, XX, and 21p12+. This patient was a 16-year-old woman with an unremarkable family history. Further investigations revealed no extragenital malformations.

1. VCUAM classification

Clinical examination of the vagina was performed in 78 patients, revealing a stage 5b (complete atresia) vagina in 21.8% of the patients, whereas 78.2% of the patients displayed a stage 4 (hypoplasia) vagina. None of the patients had a cervix. Imaging results revealed 85 patients (88.5%) with stage 4b (bilateral rudimentary or aplastic), two patients (2.1%) with stage 4a (unilateral rudimentary or aplastic), and nine patients with stage 3 (hypoplastic uterus) uterine anomalies. None of the images showed functional endometrial activity within the Müllerian structures. None of the patients showed abnormal adnexal masses on imaging.
Regarding malformations associated with MRKH syndrome (Table 2), 76 of 96 patients (79.0%) were completely evaluated using both urinary tract and skeletal imaging. Furthermore, 61 of the 76 patients (80.3%) had no extragenital malformations and were diagnosed with MRKH type I (typical form), whereas 15 of the 76 patients (19.7%) were diagnosed with MRKH type II (atypical form). Only one patient had a combination of malformations (renal and skeletal). Skeletal malformations were the most frequent extragenital anomalies (15/77, 19.5%), with scoliosis being the most common skeletal abnormality, followed by renal alterations (7/82, 8.5%). A neurological abnormality was found in one patient, diagnosed with congenital anomalies of the craniovertebral junction. One patient exhibited abnormally located ovaries.

2. Treatment

Half of the patients included in this study received no treatment because they had not engaged in sexual intercourse. Among the cohort, 41.7% had no difficulty performing sexual intercourse; thus, self-dilatation therapy or coital dilatation was advised. Only eight patients (8.3%) underwent surgical reconstruction of the vagina owing to the failure of primary dilatation therapy or their preference for surgery.

Discussion

This study included 96 women diagnosed with MRKH syndrome according to the VCUAM classification. The clinical presentation of MRKH syndrome is complex and highly heterogeneous, with varying rates and degrees of vaginal atresia and extragenital malformations. In this study, the rate of extragenital malformations was 19.7%, with skeletal abnormalities being the most common.
In our cohort, the median age at the time of diagnosis was 21 years, and this is consistent with previous studies that have reported the average age at the time of diagnosis to range from 17.2-26.2 years [4,11,12,14-17]. The late age at the time of diagnosis may be explained by the fact that women with MRKH syndrome usually present with primary amenorrhea without abdominal pain. Moreover, they displayed normal pubertal development, including growth spurt and breast development. Therefore, the absence of menstruation may not be perceived as a problem by these women. Patients with MRKH syndrome generally present with primary amenorrhea, inability to engage in sexual intercourse, and dyspareunia. Occasionally, they may also present with cyclical pelvic pain due to functional endometrial activity within the remnants of the Müllerian structures [1]. Primary amenorrhea was the most common symptom in our cohort, followed by the inability to engage in sexual intercourse and dyspareunia. Interestingly, two patients in our cohort (aged 39 and 51 years) presented with palpable abdominal masses. They had well-developed secondary sexual characteristics, but had never commenced menstruation. Pelvic examination revealed a blind-ended vaginal pouch in both the individuals. Chromosomal analysis revealed the 46, XX karyotype in both patients. The provisional diagnosis was solid ovarian tumor in both cases, and the patient underwent surgical excision. However, exploratory laparotomy revealed rudimentary uteri with fibroids; the histological diagnoses were uterine leiomyoma and adenomyosis arising from the rudimentary uterus in both cases. The presence of leiomyoma and adenomyosis in MRKH syndrome is rare, and only a few cases have been reported in the literature [18,19]. However, the exact pathogenesis of leiomyomas or adenomyoses in the rudimentary uterus of patients with MRKH syndrome remains unclear.
Evaluation of adolescents with primary amenorrhea includes hormonal measurements to assess ovarian function, chromosomal analysis, and imaging to assess the presence of a uterus [7]. The estradiol levels in our study were within the normal range, indicating normal ovarian function due to their separate embryological development. However, their anatomical position has been noted to be more cranial, probably owing to the lack of fallopian tube development [4]. We found that 1% of the patients had ovarian abnormalities (abnormally located ovaries), which is concordant with the findings of Wang et al. [20] who reported a higher incidence of abnormally located ovaries in patients with MRKH syndrome. Previously reported ovarian anomalies include hypoplastic or aplastic ovaries [12,13].
The choice of imaging modality employed, including USG and MRI, differed between patients in our study. Most patients underwent transabdominal USG because they had not previously engaged in sexual intercourse or had complete vaginal atresia. If the USG images were inconclusive, or if the clinician suspected an obstructed rudimentary uterus, MRI was performed. Uterine remnants were reported in 6.2% and 41.7% of our patients, as detected by transabdominal USG and MRI, respectively, which was lower than that reported in previous studies indicating uterine remnants in 48-95% of patients [11,21,22]. Moreover, none of the patients exhibited functional endometrial activity.
Chromosomal analysis was necessary to exclude a diagnosis of androgen insensitivity syndrome (AIS). AIS generally presents with primary amenorrhea, a shortened vagina, and an absent cervix. Moreover, patients with AIS have normal breast development owing to the aromatization of testosterone to estrogen. We found that normal 46, XX karyotypes were present in 99% of cases in this cohort, with an abnormal karyotype being present in one case (46, XX, and 21p12+), and this rate was similar to that reported in previous studies (0.3-1.4%) [4,13,15,16]. The patient with the abnormal karyotype had presented with amenorrhea and an unremarkable family history. Further investigation revealed no extragenital malformations. Previous studies have revealed aberrations in different chromosomal regions, including 1q21.1, 16p11.2, 17q12, and 22q11.21 microduplications and deletions in patients with MRKH [23]. To the best of our knowledge, 21p chromosomal variants have never been reported to be associated with MRKH syndrome. Overall, these findings suggest the presence of chromosomal aberrations in patients with MRKH syndrome.
Regarding extragenital malformations, this study showed that only 19.7% of the patients had atypical MRKH syndrome (type II). Previous large epidemiological studies on MRKH syndrome were predominantly based on data from European countries [6,11-15], with two studies from China [16,17]. Type II MRKH syndrome accounted for 27.8-55.4% of the participants from Europe, which was higher than that in the Chinese population (7.2-28.1%) (Table 3). These findings suggest that there are substantial differences across ethnicities [17]. The rate of extragenital malformations was also lower in our study (19.7%) compared to that in the European population [6,11-15]. Moreover, skeletal malformations were the most common abnormalities in our study (19.5%), in contrast to most previous studies that reported renal abnormalities as the most common extragenital malformations [4,11-16]. This difference in the incidence and types of extragenital malformations could be due to selection bias (single-center case series), incomplete data on malformations, or ethnicity. To the best of our knowledge, the congenital anomalies of the craniovertebral junction reported here in one patient have not been previously described in association with MRKH syndrome.
Patients with MRKH syndrome require a functional vagina to improve their quality of life, particularly their sexual function. Complete vaginal atresia was observed in 21.8% of our cohort; however, this rate was lower than that reported in previous studies, where complete vaginal atresia was present in 100% of the patients with MRKH syndrome [12,16]. Phenotypic manifestations also appear to vary in terms of the severity of vaginal atresia. The treatment recommended for patients with MRKH syndrome is psychological counseling and support upon diagnosis as well as creating a functional vagina to improve sexual function. Most patients in our cohort were advised regarding self-dilatation therapy or coital dilatation according to the recommendations of the American College of Obstetricians and Gynecologists committee [7]. Vaginal elongation by dilatation is the appropriate first-line approach in most patients because it is safer and generally achieves satisfactory results with a low risk of complications. However, surgery should be reserved for patients for whom primary dilatation therapy has failed or who primarily prefer surgery.
Our study has several limitations, including its retrospective design and the varying imaging modalities used among the patients. Moreover, 20.8% of patients remained unclassified because of a lack of urinary tract and/or skeletal imaging. Therefore, the number of patients with atypical MRKH syndrome might have been underestimated.
In conclusion, our study confirmed the complexity and heterogeneity of the MRKH phenotypic manifestations, including the degree of vaginal atresia and the types and rates of associated malformations.

Notes

Conflict of interest

The authors declare no conflicts of interest for this article.

Ethical approval

This study was approved by the Institutional Review Board of the Faculty of Medicine of our institution (REC. 65-367-12-1).

Patient consent

Informed consent was waived due to the retrospective nature of the study.

Funding information

This research received no specific grant from any funding agency.

Fig. 1
Flow chart of the study design. MRKH, Mayer-Rokitansky-Küster-Hauser.
ogs-23211f1.jpg
Table 1
Characteristics of patients with Mayer-Rokitansky-Küster-Hauser syndrome (n=96)
Number of patients with available data Value
Demographic data 96
 Age (yr) 21.0 (17.0-24.0)
 Height (cm) 155.6±6.2
 Weight (kg) 50.7 (45.1-56.5)
 Body mass index (kg/m2) 21.1 (19.1-23.4)
 Never had sexual intercourse 48 (50.0)
 History of hormonal exposure 5 (5.2)
Primary symptom 96
 Primary amenorrhea 85 (88.5)
 Inability to coitus/dyspareunia 9 (9.4)
 Pelvic mass 2 (2.1)
Breast tanner stage 96
 Stage 3 6 (6.2)
 Stage 4 74 (77.1)
 Stage 5 16 (16.7)
Pubic hair tanner stage 96
 Stage 2 1 (1.1)
 Stage 3 7 (7.3)
 Stage 4 80 (83.3)
 Stage 5 8 (8.3)
Estradiol levels (pg/mL) 50 72.6 (51.7-220.9)
Follicle-stimulating hormone (mIU/mL) 52 4.8 (2.9-6.2)
Pelvic examination results 78
 No uterus with vaginal pouch presence 61 (78.2)
  Vaginal pouch (cm) 3 (2.0-6.0)
 No uterus and complete vaginal atresia 17 (21.8)
Transabdominal ultrasonography results 80
 Inconclusive results 2 (2.5)
 Absence of uterus 73 (91.3)
 Presence of rudimentary or hypoplasia uterus 5 (6.2)
Transvaginal ultrasonography results 16
 Absence of uterus 14 (87.5)
 Presence of rudimentary or hypoplasia uterus 2 (12.5)
Pelvis MRI results 36
 Absence of uterus 21 (58.3)
 Presence of rudimentary or hypoplasia uterus 15 (41.7)
Karyotype 96
 46, XX 95 (99.0)
 46, XX, and 21p12+ 1 (1.0)

Values are presented as mean±standard deviation, median (interquartile range), number (%).

MRI, magnetic resonance imaging

Table 2
Associated malformations and treatment in patients diagnosed with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome (n=96)
Number of patients with available data Value
MRKH type 76a)
 Typical (type I) 61 (80.3)
 Atypical (type II) 15 (19.7)
Associated malformations
 Kidney malformation 82b) 7 (8.5)
  Unilateral renal agenesis 1 (1.2)
  Pelvic kidney 2 (2.4)
  Unilateral renal agenesis and pelvic kidney 1 (1.2)
  Duplex kidney 2 (2.4)
  Abnormal renal rotation 1 (1.2)
 Skeletal malformation 77c) 15 (19.5)
  Scoliosis 9 (11.7)
  L5 sacralization 2 (2.6)
  Spina bifida of L5 body 1 (1.3)
Treatment 96
 No treatment (never had sexual intercourse) 48 (50.0)
 Self-dilatation or coital dilatation 40 (41.7)
 Surgery 8 (8.3)

Values are presented as number (%).

a) Both urinary tract and skeletal imaging was performed in 76 of 96 patients.

b) Urinary tract imaging was performed in 82 of 96 patients.

c) Skeletal imaging was performed in 77 of 96 patient

Table 3
Studies investigating the degree of vaginal atresia and associated anomalies of Mayer-Rokitansky-Küster-Hauser syndrome
Study Population Total case Age at the first visit (yr) Degree of vaginal atresia Type II (associated malformation) Extragenital malformation
Renal Skeletal Cardiac Hearing
Creatsas et al. [11] (2010) Greece 200 17.2 -Depth <2 cm in 78.5
-Depth 3 cm in 22.5
NA 44.5 9.0 4.5
Oppelt et al. [12] (2012) Germany 284 26.2 100 complete vaginal atresia 44.4 29.6 19.0 3.5
Rall et al. [13] (2015) Germany 346 NA NA 46.8 26.6 20.5 2.6 4.0
Lalatta et al. [14] (2015) Italy 115 22.0 NA 27.8 20.0 5.2a) 5.2 3.5
Kapczuk et al. [15] (2016) Poland 125 NA NA 54.4 28.8 32.0 4.0 3.2
Herlin et al. [6] (2016) Denmark 304 17.5 NA 43.5b) 34.2c) 12.5 3.6 1.8
Pan and Luo [16] (2016) China 594 24.7 100 complete vaginal atresia 7.2 5.2 2.0 0.5
Deng et al. [17] (2019) China 274 23.0 NA 28.1 13.1d) 40.8e) 1.5 0.4
Current study Thailand 96 21.0 -21.8 complete vaginal atresia
-78.2 partial vaginal atresia with median length of 3 cm
19.7 8.5f) 19.5g)

NA, not available.

a) Scoliosis was excluded as a skeletal malformation.

b) Fifty-three patients were not classified.

c) Urinary tract imaging was performed in 111 of 168 patients.

d) Urinary tract imaging was performed in 244 of 274 patients.

e) Skeletal imaging was performed in 125 of 274 patients.

f) Urinary tract imaging was performed in 82 of 96 patients.

g) Skeletal imaging was performed in 77 of 96 patients.

References

1. Choussein S, Nasioudis D, Schizas D, Economopoulos KP. Mullerian dysgenesis: a critical review of the literature. Arch Gynecol Obstet 2017;295:1369-81.
crossref pmid pdf
2. Aittomäki K, Eroila H, Kajanoja P. A population-based study of the incidence of Müllerian aplasia in Finland. Fertil Steril 2001;76:624-5.
crossref pmid
3. Timmreck LS, Reindollar RH. Contemporary issues in primary amenorrhea. Obstet Gynecol Clin North Am 2003;30:287-302.
crossref pmid
4. Herlin MK, Petersen MB, Brännström M. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: a comprehensive update. Orphanet J Rare Dis 2020;15:214.
crossref pmid pmc pdf
5. Acién P, Acién M. The presentation and management of complex female genital malformations. Hum Reprod Update 2016;22:48-69.
crossref pmid
6. Herlin M, Bjørn AM, Rasmussen M, Trolle B, Petersen MB. Prevalence and patient characteristics of Mayer-Rokitansky-Küster-Hauser syndrome: a nationwide registry-based study. Hum Reprod 2016;31:2384-90.
crossref pmid
7. Committee on Adolescent Health Care. ACOG committee opinion no. 728: Müllerian agenesis: diagnosis, management, and treatment. Obstet Gynecol 2018;131:e35-42.
crossref pmid
8. Preibsch H, Rall K, Wietek BM, Brucker SY, Staebler A, Claussen CD, et al. Clinical value of magnetic resonance imaging in patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: diagnosis of associated malformations, uterine rudiments and intrauterine endometrium. Eur Radiol 2014;24:1621-7.
crossref pmid pdf
9. Patterson CJ, Crawford R, Jahoda A. Exploring the psychological syndrome on young women: an interpretative phenomenological analysis. J Health Psychol 2016;21:1228-40.
crossref pmid pdf
10. Ernst ME, Sandberg DE, Keegan C, Quint EH, Lossie AC, Yashar BM. The lived experience of MRKH: sharing health information with peers. J Pediatr Adolesc Gynecol 2016;29:154-8.
crossref pmid
11. Creatsas G, Deligeoroglou E, Christopoulos P. Creation of a neovagina after Creatsas modification of Williams vaginoplasty for the treatment of 200 patients with Mayer-Rokitansky-Kuster-Hauser syndrome. Fertil Steril 2010;94:1848-52.
crossref pmid
12. Oppelt PG, Lermann J, Strick R, Dittrich R, Strissel P, Rettig I, et al. Malformations in a cohort of 284 women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH). Reprod Biol Endocrinol 2012;10:57.
crossref pmid pmc pdf
13. Rall K, Eisenbeis S, Henninger V, Henes M, Wallwiener D, Bonin M, et al. Typical and atypical associated findings in a group of 346 patients with Mayer-Rokitansky-Kuester-Hauser syndrome. J Pediatr Adolesc Gynecol 2015;28:362-8.
crossref pmid
14. Lalatta F, Motta F, Restelli E, Bellini M, Miozzo M, Gervasini C, et al. Dysmorphologic assessment in 115 Mayer-Rokitansky-Küster-Hauser patients. Clin Dysmorphol 2015;24:95-101.
crossref pmid
15. Kapczuk K, Iwaniec K, Friebe Z, Kędzia W. Congenital malformations and other comorbidities in 125 women with Mayer-Rokitansky-Küster-Hauser syndrome. Eur J Obstet Gynecol Reprod Biol 2016;207:45-9.
crossref pmid
16. Pan HX, Luo GN. Phenotypic and clinical aspects of Mayer-Rokitansky-Küster-Hauser syndrome in a Chinese population: an analysis of 594 patients. Fertil Steril 2016;106:1190-4.
crossref pmid
17. Deng S, He Y, Chen N, Zhu L. Spectrum of type I and type II syndromes and associated malformations in Chinese patients with Mayer-Rokitansky-Küster-Hauser syndrome: a retrospective analysis of 274 cases. J Pediatr Adolesc Gynecol 2019;32:284-7.
crossref pmid
18. Kulkarni MM, Deshmukh SD, Hol K, Nene N. A rare case of Mayer-Rokitansky-Kuster-Hauser syndrome with multiple leiomyomas in hypoplastic uterus. J Hum Reprod Sci 2015;8:242-4.
crossref pmid pmc
19. Blontzos N, Iavazzo C, Vorgias G, Kalinoglou N. Leiomyoma development in Mayer-Rokitansky-Küster-Hauser syndrome: a case report and a narrative review of the literature. Obstet Gynecol Sci 2019;62:294-7.
crossref pmid pmc pdf
20. Wang Y, Lu J, Zhu L, Chen R, Jiang B, Hou B, et al. Increased incidence of abnormally located ovary in patients with Mayer-Rokitansky-Küster-Hauser syndrome: a retrospective analysis with magnetic resonance imaging. Abdom Radiol (NY) 2018;43:3142-6.
crossref pmid pdf
21. Wang Y, He YL, Yuan L, Yu JC, Xue HD, Jin ZY. Typical and atypical pelvic MRI characteristics of Mayer-Rokitansky-Küster-Hauser syndrome: a comprehensive analysis of 201 patients. Eur Radiol 2020;30:4014-22.
crossref pmid pdf
22. Marsh CA, Will MA, Smorgick N, Quint EH, Hussain H, Smith YR. Uterine remnants and pelvic pain in females with Mayer-Rokitansky-Küster-Hauser syndrome. J Pediatr Adolesc Gynecol 2013;26:199-202.
crossref pmid
23. Ledig S, Wieacker P. Clinical and genetic aspects of Mayer-Rokitansky-Küster-Hauser syndrome. Med Genet 2018;30:3-11.
crossref pmid pmc pdf


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