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Obstet Gynecol Sci > Volume 54(10); 2011 > Article
Korean Journal of Obstetrics & Gynecology 2011;54(10):605-610.
DOI: https://doi.org/10.5468/KJOG.2011.54.10.605    Published online October 1, 2011.
The etiological classification of amenorrhea in Korean women.
Su Kyoung Kwon, Sun Joo Lee, Eun Jin Jun, Kyoung Hee Lee, Rae Mi Ryu, Hyuk Jae Kang, Sung Hun Kim, Hee Dong Chae, Chung Hoon Kim, Byung Mun Kang
Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hdchae@amc.seoul.kr
To investigate the causes of amenorrhea in Korean women. METHODS: A total of 741 patients with amenorrhea who visited the department of Obstetrics and Gynecology, Asan Medical Center were included in this study between January 1998 and May 2008. Patients were divided into three groups: age 10-20 was defined as group I, age 21-30 was group II and age 31-40 was group III. Amenorrhea was categorized into the primary amenorrhea and secondary amenorrhea. RESULTS: The number of patients with primary amenorrhea was 89 (12.0%) and secondary amenorrhea was 652 (88.0%). The number of patients with primary amenorrhea was 62 (22.6%) and secondary amenorrhea was 212 (77.4%) in age 10-20 group. In age 21-30 group, the number of primary amenorrhea was 27 (6.5%) and secondary amenorrhea was 389 (93.5%). In age 31-40 group, the number of secondary amenorrhea was 51 (100%). The causes of primary amenorrhea in group I were as follows; Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome (17.7%, 11/62), Turner syndrome (11.3%, 7/62), constitutional delay (9.7%, 6/62). In group II; MRKH syndrome (18.5%, 5/27), Turner syndrome (18.5%, 5/27), and Idopathic hypogonadotropic hypogonadism (14.8%, 4/27). The causes of secondary amenorrhea in group I were as follows; Polycystic ovarian syndrome (PCOS; 60.8%, 129/212), weight related hypogonadotropic hypogonadism (12.3%, 26/212), premature ovarian failure (POF; 9.9%, 21/212). In group II; PCOS (62.5%, 243/389), weight related hypogonadotropic hypogonadism (9.8%, 38/389), POF (9.3%, 36/389). In group III; POF (43.1%, 22/51), PCOS (17.6%, 9/51). CONCLUSION: The common cause of primary amenorrhea were MRKH syndrome, Turner's syndrome, and the common cause of secondary amenorrhea were PCOS, POF, weight related hypogonadotropic hypogonadism.
Key Words: Amenorrhea, Causes

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