Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report.

Shin, Yoo Jeong; Cho, Se Eun; Sung, Chang Ohk; Choi, Chel Hun; Bae, Duk Soo

doi:2011.54.9.561

Obstet Gynecol Sci > Volume 54(9); 2011 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2011;54(9):561-565.
DOI: https://doi.org/10.5468/KJOG.2011.54.9.561 Published online September 1, 2011.

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report.

Yoo Jeong Shin, Se Eun Cho, Chang Ohk Sung, Chel Hun Choi, Duk Soo Bae

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ds123.bae@samsung.com

Abstract

The incidence of cancer from adenomyosis is rare. Previously, only two cases of clear cell adenocarcinoma (CCA) arising from adenomyosis have been reported in English literature. Here, we report a case of CCA arising from adenomyosis. A 52-year-old postmenopausal Korean woman presented with complaints of vaginal bleeding and back pain. Endometrial biopsy revealed endometrial polyp with atrophic change and transvaginal ultrasonography showed myomas with cystic change. Magnetic resonance imaging revealed a cystic degenerative mass consistent with leiomyoma in the posterior portion of uterus body. And the serum level of CA-125 was 17.7 U/mL. Hysterectomy revealed a yellow-ten solid mass in the myometrium that was diagnosed as CCA arising from adenomyosis. The tumor was mainly located in the myometrium and transition between adenomyosis and CCA along with endometrial stromal cell was identified. Malignant tumor arising from adenomyosis could be considered as a differential diagnosis when the patient with adenomyosis and intact endometrial surface complained of vaginal bleeding.

Key Words: Adenocarcinoma, clear cell, Endometriosis, Eestrogen receptor, Progesterone receptor, p53