Angiomyofibroblastoma of the uterine cervix in a breast cancer patient: A case report.

Kim, Min Ji; Kuk, Ji Ni; Sung, Ji Hyun; Hyun, Chang Lim; Shim, Soon Sup; Park, Chul Min; Kim, Sung Yob

doi:2011.54.6.330

Obstet Gynecol Sci > Volume 54(6); 2011 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2011;54(6):330-333.
DOI: https://doi.org/10.5468/KJOG.2011.54.6.330 Published online June 1, 2011.

Angiomyofibroblastoma of the uterine cervix in a breast cancer patient: A case report.

Min Ji Kim, Ji Ni Kuk, Ji Hyun Sung, Chang Lim Hyun, Soon Sup Shim, Chul Min Park, Sung Yob Kim

¹Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
²Department of Pathology, Jeju National University School of Medicine, Jeju, Korea.
³Department of Obstetrics and Gynecology, Jeju National University School of Medicine, Jeju, Korea. kimsy@cheju.ac.kr

Abstract

Angiomyofibroblastoma (AMFB) is a rare mesenchymal tumor mostly involving the female lower genital tract. Although a large number of cases of vulva and vagina has been reported, a report on a case of the uterine cervix is uncommon. Despite unknown pathogenesis of AMFB, positive immunoreactivity for hormonal receptor of AMFB allows to make an assumption that the hormonal stimuli may have a role on the development of AMFB. Therefore, it is potential that estrogenic effect of tamoxifen gives stimuli on hormonally responsible mesenchymal cells, resulting in AMFB. We report a case of AMFB of the uterine cervix in a breast cancer patient with prolonged tamoxifen treatment with brief literature review.

Key Words: Angiomyofibroblastoma, Cervix uteri, Breast neoplasm, Tamoxifen