Histologic comparison of polycystic ovary syndrome induced by estradiol valerate and letrozole.

Lim, Sung Chul; Jeong, Moon Jin; Kim, Se Eun; Kim, Seung Hyun; Kim, Sam Cheol; Seo, Seung Yong; Kim, Tak; Kang, Seong Soo; Bae, Chun Sik

doi:2011.54.6.294

Obstet Gynecol Sci > Volume 54(6); 2011 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 2011;54(6):294-299.
DOI: https://doi.org/10.5468/KJOG.2011.54.6.294 Published online June 1, 2011.

Histologic comparison of polycystic ovary syndrome induced by estradiol valerate and letrozole.

Sung Chul Lim, Moon Jin Jeong, Se Eun Kim, Seung Hyun Kim, Sam Cheol Kim, Seung Yong Seo, Tak Kim, Seong Soo Kang, Chun Sik Bae

¹Department of Pathology, Chosun University College of Medicine, Gwangju, Korea.
²Department of Oral Histology, Chosun University College of Dentistry, Gwangju, Korea.
³Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine, Gwangju, Korea. csbae210@chonnam.ac.kr
⁴Department of Medicine, Graduate School Chosun University, Gwangju, Korea.
⁵Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.

Abstract

OBJECTIVE
To compare ovarian morphology of the estradiol valerate (EV)- and the letrozole (LE)-induced polycystic ovary syndrome (PCOS) in rat models. METHODS: EV were injected (IM) to 10 Sprague-Dawley rats and LE were administered (PO) to the other 10 Sprague-Dawley rats for 21 days. Sixty days after single injection of EV and 21 days after LE administration, the animals were sacrificed and the ovaries were sectioned, measured and analyzed histopathologically. RESULTS: LE-treated group showed larger ovary bearing more abundant cystic follicles with luteinized theca cells. These findings were more similar to human PCOS ovarian morphology. CONCLUSION: LE-induced PCOS model is recommended to conduct PCOS-related animal experiments.

Key Words: Polycystic ovary syndrome, Estradiol valerate, Letrozole, Ovary