| The prognostic significance of p16, Ki-67, p63, and CK17 expression determined by immunohistochemical staining in cervical intraepithelial neoplasia 1. |
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Su Mi Kim, Jeong Uee Lee, Dae Woo Lee, Min Jung Kim, Hae Nam Lee |
1Department of Obstetrics and Gynecology, Bucheon St. Mary's Hospital, The Catholic University of Korea School of Medicine, Bucheon, Korea. leehaenam@catholic.ac.kr
2Department of Pathology, Daejeon St. Mary's Hospital, The Catholic University of Korea School of Medicine, Daejeon, Korea. |
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| Abstract |
OBJECTIVE
To evaluate the prognostic significance of p16, Ki-67, p63, and cytokeratin (CK) 17 expression determined by immunohistochemical staining in cervical intraepithelial neoplasia (CIN) 1. METHODS: Biopsy tissue samples from 33 patients diagnosed with CIN 1 were stained immunohistochemically for p16, Ki-67, p63, and CK17. The staining results were correlated with the clinical course of the disease. RESULTS: Seventeen of 18 (94.4%) p16-negative patients experienced regression, and only 1 patient (5.6%) developed persistent disease. Fifteen of the 16 (93.8%) Ki-67-negative patients experienced regression, and 1 patient (6.3%) developed persistent disease. Negative p16 and Ki-67 expression correlated significantly with disease regression (P=0.004 and P=0.017, respectively). Fourteen of 15 (93.3%) patients negative for both p16 and Ki-67 experienced regression, and 1 patient negative for both p16 and Ki-67 (6.7%) developed persistent disease. The expression levels of p63 and CK17 were not significantly associated with disease regression or persistence (P=0.149 and P=0.642, respectively). Ten of the 13 (76.9%) p16-positive patients had a high-risk HPV infection. High-risk HPV infection was significantly associated with p16 expression (P=0.049). CONCLUSION: CIN 1 with p16- or Ki-67-negative immunohistochemical staining was associated with spontaneous disease regression. The p63 and CK17 expression patterns were not related to the behavior of CIN 1. |
| Key Words:
Cervical intraepithelial neoplasia 1, p16, Ki-67, p63, Cytokeratin 17 |
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