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Obstet Gynecol Sci > Volume 54(1); 2011 > Article
Korean Journal of Obstetrics & Gynecology 2011;54(1):26-36.
DOI: https://doi.org/10.5468/KJOG.2011.54.1.26    Published online January 1, 2011.
Maternal serum levels of C-reactive protein and placental levels of IL-6, lipid peroxide, and protein carbonyl in preterm birth according to histologic chorioamnionitis.
Dae Seok Yoon, Yoon Ha Kim, Chul Hong Kim, Moon Kyoung Cho, Jong Woon Kim, Hye Yon Cho, Seok Mo Kim, Woo Dae Kang, Ki Ho Lee, Tae Bok Song
1Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. kimyh@chonnam.ac.kr
2Department of Obstetrics and Gynecology, Seonam University College of Medicine, Namwon, Korea.
Abstract
OBJECTIVE
To evaluate predictive value of maternal serum white blood cells (WBCs), C-reactive protein (CRP) levels, placental interleukin-6 (IL-6), lipid peroxide, and protein carbonyl levels in preterm birth according to histologic chorioamnionitis (HCA). METHODS: This cohort study included 45 cases of preterm delivery with preterm labor and intact membranes (preterm labor [PTL] group; n=16) and preterm premature rupture of membranes (preterm premature rupture of membranes [PPROM] group; n=29). Blood samples at admission and placental sample at postpartum were collected. HCA was diagnosed in the presence of neutrophils infiltration into the subamnionic space. RESULTS: The incidence of HCA was significantly higher in PPROM group than PTL group. Maternal serum WBC and CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels in HCA group were significantly higher than group without HCA. Maternal serum CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels of PPROM group with HCA were significantly higher than PPROM group without HCA. Maternal serum CRP levels at admission of 7 days and more latency period (n=14) were significantly lowered than those of less than 7 days latency period (n=15). The cut-off points of CRP determined with the receiver operating characteristic curves was 0.875 mg/dL. Perinatal morbidity such as respiratory distress syndrome, intraventricular hemorrhage, pneumonia in HCA group was significantly higher than group without HCA. CONCLUSION: Maternal serum CRP on admission may be possible a predictor for duration of the latency period in PPROM.
Key Words: Preterm birth, Histologic chorioamnionitis, C-reactive protein, Lipid peroxides, Protein carbonyls
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