Obstetrics & Gynecology Science

Original Article: Korean J Obstet Gynecol. 2008;51(11):1302-1308. Published online November 1, 2008.; Value of Human Papilloma Virus load in hybrid capture II assay to predict high grade cervical intraepithelial neoplasia in menopausal women with ASCUS or LSIL.; Hae Nam Lee, In Cheul Jeung, Yong Sek Lee, Eun Kyung Park, Chan Joo Kim, Jong Sup Park, Sung Eun Namkoong; ¹Department of Obstetrics and Gynecology, Daejeon St. Mary's Hospital, Catholic University Medical College, Seoul, Korea. leehaenam@catholic.ac.kr
²Department of Obstetrics and Gynecology, St. Paul's Hospital, Catholic University Medical College, Seoul, Korea.
³Department of Obstetrics and Gynecology, Kangnam St. Mary's Hospital, Catholic University Medical College, Seoul, Korea.

Abstract: OBJECTIVE
To evaluate whether determination of the Human Papilloma Virus (HPV) viral load is helpful to predict the presence of high-grade cervical intraepithelial neoplasia (CIN) that requires aggressive treatment in menopausal women who have presented with an unsatisfactory colposcopic finding and ASCUS or LSIL. METHODS: In menopausal women with ASCUS or LSIL and with who were positive for HPV, 54 women had diagnostic conization were analyzed retrospectively. We used the Hybrid Capture II method. We classified women in a low-risk group (chronic cervicitis, CIN I) and a high-risk group (> or =CIN II) according to the pathological results of conization. We also classified patients into the HPV viral load <100 RLU/PC group and > or =100 RLU/PC group. We analyzed the relationship between the pathological results of conization and viral load. RESULTS: For the conization, 30 women had chronic cervicitis, nine women had CIN I, three women had CIN II and 12 women had CIN III. In the low Hybrid Capture titer-group (<100 RLU/PC), four women had high risk > or =CIN II pathology but in the high Hybrid Capture titer-group (> or =100 RLU/PC), 11 women had high risk pathology this finding was statistically significant (P=0.013). Compared to the low Hybrid Capture titer group, the relative risk of high grade CIN (> or =CIN II) in the high Hybrid Capture titer group was 2.043 (95% CI, 1.216~3.432). CONCLUSIONS: For menopausal women with an unsatisfactory colposcopic finding and also have ASCUS or LSIL women with high HPV viral load might have tendency of > or =CIN II pathology.

Keywords :Menopause;HPV viral load;CIN