-
Original Article
-
Korean J Obstet Gynecol. 2007;50(8):1100-1106. Published online August 1, 2007.
- The clinicopathological relevance of Poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer.
-
Su Il Shin, Hye In Chong, Jeong Tae Kim, Dong Soo Suh, Man Soo Yoon, Kyung Un Choi, Chang Hun Lee
-
1Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@webmail.pusan.ac.kr
2Department of Pathology, College of Medicine, Pusan National University, Busan, Korea.
- Abstract
- OBJECTIVE
To evaluate the clinicopathological implication of poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer. METHODS: Retrospectively, slide samples (n=72) were analyzed. PARP expression was analyzed using immunohistochemical staining. RESULTS: Of 72 cases, positive PARP expression were 27 cases (37.5%). PARP expression showed negative correlation with FIGO stage (p=0.004) and mitotic count (p=0.010), but showed no correlation with grade (p=0.053), tumor size (p=0.301), Ki-67 LIs (p=0.986), p53 positivity (p=0.414), and bcl-2 positivity (p=0.413). CONCLUSION: PARP expression showed negative correlation with advanced stage and mitoses in epithelial ovarian cancer. Therefore PARP expression could be a new prognostic factor in epithelial ovarian cancer.
Keywords :PARP;Epithelial ovarian cancer
