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Original Article
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Korean J Obstet Gynecol. 2007;50(1):85-92. Published online January 1, 2007.
- Relationship between spontaneous preterm birth and polymorphisms of Interleukin-1beta and Interleukin-1 receptor antagonist in Korean women.
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Se Ryun Kim, Young Jun Park, Ki Young Ryu, Jong Wook Kim, Eun Seob Song, Byung Ick Lee
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1Department of Obstetrics & Gynecology, Kwandong University, Myongji Hospital, Korea. bluebell@kwandong.ac.kr
2Department of Obstetrics & Gynecology, Inha University Hospital, Korea.
- Abstract
- OBJECTIVE
Preterm birth is an important cause of infant death and morbidity but its pathophysiology still remains to be clear. The associations between preterm birth and the polymorphism of interleukin-1beta gene and interleukin-1 receptor antagonist gene have been suspected. And ethnic variations in the polymorphism of the genes were also reported. We decided to study polymorphisms of interleukin-1beta+3953 and interleukin-1 receptor antagonist in Korean pregnant women. METHODS: Patients were divided into 2 groups. Group 1 is the control group of 33 subjects with uncomplicated term delivery : group 2 is the case group of patients who had spontaneous preterm delivery. Polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism analysis. RESULTS: There were significant differences in gestational age and birth weight between two groups (P<0.001). No significant differences were found in genotypic frequencies and allelic frequencies in interleukin-1beta+3953 between two groups. Interleukin-1 receptor antagonist gene had 5 alleles and the most frequent allele was IL1RN*1 (410bp), 66.7% in control group and 77.8% in case group. And significant differences were not found in genotypic frequencies and allelic frequencies between two groups, too. CONCLUSION: There were no significant differences in polymorphisms in interleukin-1beta +3953 and interleukin-1 receptor antagonist between term delivery group and preterm birth group.
Keywords :preterm birth;polymorphism;interleukin-1beta;interleukin-1 receptor antagonist
