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Original Article
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Korean J Obstet Gynecol. 2005;48(12):2813-2819. Published online December 1, 2005.
- Leptin and growth hormone in the cord blood of healthy neonates: correlation with fetal growth.
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Se Ryun Kim, Ji Hyun Park, Young Jun Park, Ki Young Ryu, Jong Wook Kim, Byung Ick Lee, Sook Cho
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1Department of Obstetrics and Gynecology, Kwandong University, Myongji Hospital, Korea. bluebell@kwandong.ac.kr
2Department of Obstetrics and Gynecology, Inha University Hospital, Korea.
3Department of Obstetrics and Gynecology, Seoul Medical Center, Korea.
- Abstract
- OBJECTIVE
To understand the correlation between leptin in cord blood and parameters indicating fetal growth and to investigate the relationship between leptin and growth hormone. METHODS: We measured leptin and growth hormone levels in the cord blood of 46 healthy neonates by radioimmunoassay (RIA), and analyzed the correlation of leptin with growth hormone, birth weight, gestational age, sex, birth height, body mass index, maternal body mass index (BMI), and Ponderal Index by Pearson correlation coefficients. RESULTS: Leptin concentration of cord blood was 5.16 g/l in median value; concentration in female cord blood was significantly higher than in male's (P=0.005). Growth hormone concentration was 28.60 g/l; there was no significant difference between female and male (P=0.584). There were significant correlations between leptin and birth weight, birth height, and BMI at birth, with correlation coefficients 0.56 (P=0.0001), 0.35 (P=0.017), and 0.35 (P=0.017), respectively. Growth hormone was correlated with leptin but statistically insignificant (P=0.085). And growth hormone was not correlated with gestational age, Ponderal Index or maternal BMI. CONCLUSION: Leptin is significantly correlated with fetal growth, and growth hormone is potentially correlated with fetal growth.
Keywords :Leptin;Growth hormone;Fetal growth
