-
Case Report
-
Korean J Obstet Gynecol. 2005;48(6):1555-1562. Published online June 1, 2005.
- A Case of Endometrial Cancer with Hereditary Non-Polyposis Colorectal Cancer (HNPCC).
-
Jae Hee Yoon, Seon Kyung Lee, Suk Hee Lee, Seo Yun Tong, So Ra Kim, In Gu Do, Seung Bo Kim
-
1Department of Obstetrics and Gynecology, College of Medicine, Kyung Hee University, Seoul, Korea. andy2155@korea.com
2Department of Pathology, College of Medicine, Kyung Hee University, Seoul, Korea.
- Abstract
- Endometrial cancer is the most common malignant disorder that can be associated with hereditary non-polyposis colorectal cancer (HNPCC), which is known as Lynch II syndrome. HNPCC is a polyposis of the colon which is inherited in an autosomal dominant pattern and can cause cancer in other organs, especially in the endometrium. The overall risk of a women with HNPCC to develop endometrial cancer is 40-60%, much higher than the 3% of the general population of women. The average age of developing endometrial cancer of a women with HNPCC is 45 years of age and is often found before development of colon cancer. We have recently experienced a case of de novo type of hereditary non-polyposis colorectal cancer associated with endometrial cancer, hence we are reporting this case with a brief review of literatures.
Keywords :Endometrial cancer;Hereditary non-polyposis colorectal cancer (HNPCC);MSI (microsatellite instability);MMR (mismatch repair) gene
