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Original Article
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Korean J Obstet Gynecol. 2005;48(3):726-731. Published online March 1, 2005.
- CYP19 Gene Polymorphism in Patients with Endometriosis.
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Jin Ju Kim, Young Min Choi, Jun Young Hur, Seung Yup Ku, Jong Kwan Jun, Soon Beom Kang, Sung Hyo Park, Eun Ran Chang, Noh Hyun Park, Soo Youn Cho, In Ae Park, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon
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1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea. ymchoi@snu.ac.kr
2Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Korea.
3Medical Research Center, Seoul National University College of Medicine, Korea.
4Department of Pathology, Seoul National University College of Medicine, Korea.
5Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea.
- Abstract
- OBJECTIVE
To explore the association of the CYP19 gene polymorphism with the risk of endometriosis. METHODS: Two hundred seventy-nine women with surgically or histologically diagnosed endometriosis of stages I-IV (ASRM, 1997) were recruited, and two hundred eighteen patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. We analysed the frequency and distribution of a TTTA repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene. RESULTS: Six alleles of the CYP19 gene tetranucleotide repeat polymorphism were found in subjects: from 7 repeats to 13 repeats except 9 repeats. There was no statistically significant difference in the allele distribution of tetranucleotide repeat polymorphism in intron 4 of the CYP19 gene between patients with endometriosis and controls. Also there was no statistically significant difference in the 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene between patients with endometriosis and controls. CONCLUSION: These results suggest that tetranucleotide repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism of the CYP19 gene are not associated with the risk endometriosis in the Korean population.
Keywords :Endometriosis;CYP19 gene;Aromatase;TTTA repeat;3 bp I/D
