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Original Article
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Korean J Obstet Gynecol. 2004;47(5):938-945. Published online May 1, 2004.
- The Genetic Polymorphism of Alpha 2-Heremans Schmidt Glycoprotein (AHSG), and Antibody to AHSG in Patients with Endometriosis.
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Hoon Kim, Jung Gu Kim
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Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
- Abstract
- OBJECTIVE
To investigate the relationship among alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism, anti-AHSG antibody and endometriosis in Korean women. METHODS: AHSG polymorphism was analyzed by restriction fragment length polymorphism and DNA sequencing in 79 women with endometriosis, and 105 women with normal pelviscopic finding. Anti-AHSG antibody was measured using enzyme linked immuosorbent assay. RESULTS: The allele frequencies of AHSG 1 and AHSG 2 were 0.69 and 0.31 respectively. The proportion of noncarrier of AHSG 2 allele was significantly higher (p<0.05) in women with endometriosis than in women without endometriosis (55.7% versus 39.0%). Women not carrying AHSG 2 allele have 2 times higher risk of endometriosis than women carrying at least one this allele. Positive rate of anti-AHSG antibody was significantly higher in women with endometriosis (20.0%) than women without endometriosis (2.7%). There were no significant differences in the distribution of AHSG allele or AHSG genotypes and in positivity of anti-AHSG antibody between early stage endometriosis and late stage endometriosis. No significant difference in positivity of anti-AHSG antibody was noted among AHSG genotypes. CONCLUSION: AHSG polymorphism and anti-AHSG antibody is associated with endometriosis, but the positivity of anti-AHSG antibody does not depend on AHSG genotypes.
Keywords :AHSG;Endometriosis;Genetic polymorphism;Antibody