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Original Article
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Korean J Obstet Gynecol. 2002;45(12):2124-2129. Published online December 1, 2002.
- Expression of c-erbB-2 Oncoprotein and DNA Topoisomerase II-alpha in Premalignant Lesions and Invasive Squamous Cell Carcinomas of the Uterine Cervix.
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Seung Ho Shin, Hong Mo Koo, Jin Seak Kim, Hye Kyoung Mun, Jae Deok Lee, Sang Yong Kim, Jae Hee Han, Tae Il Cho, Tae Jin Lee
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1Department of Obstetrics and Gynecology, Kwang Myung Sung Ae Hospital, Seoul, Korea.
2Department of Obstetrics and Gynecology, Sung Ae General Hospital, Seoul, Korea.
3Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea.
- Abstract
- OBJECTIVE
The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix. METHODS: Total 81 formalin-fixed, paraffin-embedded sections of low-grade intrasquamous lesion (22 cases), high-grade intraepithelial lesions (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of the c-erbB-2 oncoprotein and topoisomerase II-alpha. RESULTS: The expression of c-erbB-2 oncoprotein and staining index (mean+/-S.D) of topoisomerase II-alpha were statistically significant between precancerous lesions and invasive carcinoma. The expression of c-erbB-2 oncoprotein has correlation with staining index (mean+/-S.D) of topoisomerase II-alpha. CONCLUSION: There results suggest that the expression of c-erbB-2 protein has relationship with progression of squamous lesions and topoisomerase II-alpha is an useful proliferating marker in the uterine cervix. And, the expression of c-erbB-2 protein has correlation with expression of topoisomerase II-alpha.
Keywords :c-erbB-2;topoisomerase II-alpha;uterine cervix;precancerous lesion;invasive squamous cell carcinoma
