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Randomized Controlled Trial
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Korean J Obstet Gynecol. 2002;45(8):1360-1366. Published online August 1, 2002.
- The Effects of Low Dose Estrogen Replacement Therapy on the Lipid Profile of Postmenopausal Women.
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Heung Yeol Kim, Wan Kyu Eo
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1Department of Obstetrics and Gynecology, School of Medicine, Kosin university, Busan, Korea.
2Department of Internal Medicine, School of Medicine, Kosin university, Busan, Korea.
- Abstract
- OBJECTIVE
To evaluate the effects of low dose estrogen replacement therapy on the lipid profile in the postmenopausal women. METHODS: This prospective randomized clinical trial examined the effects of low dose conjugated equine estrogen on lipid profile in 140 postmenopausal women. Treatment included 0.625 mg conjugated equine estrogen (group I, n=75), or 0.31mg conjugated equine estrogen (group II, n=55) for 12 months. Lipid profile were performed at months 6 and 12 months. RESULTS: HDL cholesterol increased significantly during the treatment in Group I and Group II. LDL cholesterol decreased significantly during the treatment in Group I and Group II. Total cholesterol in Group I and Group II decreased during treatment, but not significantly. As triglyceride increased slightly during the treatment in Group I and Group II but not significantly. CONCLUSION: The low dose conjugated equine estrogen is also positive changes on lipid profile.
Keywords :Low dose conjugated equine estrogen;Lipid profile
