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Original Article
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Korean J Obstet Gynecol. 2001;44(9):1627-1632. Published online September 1, 2001.
- A relationship between polymorphism of estrogen receptor gene and bone mineral density in premenopausal Korean women.
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Sung Eun Hur, Ho Sun Lyoo, Han Moie Park, Eun Hye Yoon, Sung Shin Shim, Hong Soo Lee, Hyung Rae Kim, Hye Won Chung
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1Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University.
2Department of Family Medicine, College of Medicine, Ewha Womans' University.
3Department of Biochemistry, College of Medicine, Ewha Womans' University.
- Abstract
- OBJECTIVE
The goal of this study was to determine the relationship between peak bone density and polymorphism of estrogen receptor gene in Korean premenopausal women. METHOD: We amplified Estrogen receptor by polymerase chain reaction and its digestion pattern of Pvu II and Xba I was examined from the 172 women who were in premenopause. The genetic subtype was classified by its digestion pattern and its combination genotype, e.g. PP, Pp, pp, XX, Xx, xx, PPXX, PPXx, PPxx, PpXx, Ppxx, xxpp. Bone mineral density of each genetic subtype were compared. RESULTS: The genotype distribution was as follows: PP; 16.3%, Pp; 45.9%, pp; 37.8%, XX; 1.2%, Xx; 25.0%, xx; 73.8%, PPXX; 1.1%, PPXx; 8.7%, PPxx; 6.4%, PpXx; 16.3%, Ppxx; 29.7%, ppxx; 37.8%. ER gene polymorphism was associated with bone mineral density at forearm bone mineral density (P<0.05) with the xx genotype having the less BMD than Xx genotype. CONCLUSION: Xba I estrogen receptor gene polymorphism is associated with bone mineral density in premenopausal women. Estrogen receptor gene polymorphism may have a modulatory role in bone metabolism in premenopausal women. And it can be used as predictor of forearm peak bone density.
Keywords :Estrogen receptor;polymorphism;peak bone mineral density
