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Original Article
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Korean J Obstet Gynecol. 2001;44(6):1091-1096. Published online June 1, 2001.
- The efficacy of nuchal translucency with free beta-hCG, PAPP-A as a screening test for detection of chromosomal anomaly in the first trimester of pregnancy.
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Sung Joo Kim, Chang Mo Kim, Bong Sik Min, Woo Seok Sohn, Jung Bae Kang, Pong Rheem Jang
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Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Sacred Heart Hospital, Korea.
- Abstract
- OBJECTIVES
The aim of this study is to determine the efficacy of nuchal translucency in combination with free beta-hCG, PAPP-A in the first trimester screening for chromosomal anomaly in general population. METHODS: Between April 1998 and December 1999, we evaluated 263 pregnant women undergoing first trimester screening test for fetal chromosomal anomaly using nuchal translucency combined with free beta-hCG, PAPP-A. We confirmed the pregnancy outcomes through chorionic villi sampling, amniocentesis or term delivery. We excluded 15 pregnant women because of their obscure pregnancy outcomes. Statistical analysis was considered significant when P value was lower than 0.05. RESULTS: With a risk cut-off of 1 in 400, 24 pregnancies(9.7%) of 248 cases were screen positive and 224 pregnancies(90.3%) were screen negative. 2 cases of Down syndrome and 1 case of Turner syndrome were detected in screen positive group. No chromosomal anomalies were detected in screen negative group. CONCLUSION: In this study, 8.57% of false positive rate and 12.5% of positive predictive value were obtained in the first trimester screening for chromosomal anomaly using nuchal translucency and serum markers.
Keywords :Nuchal translucency;Free beta-hCG;PAPP-A;Chromosomal anomaly
