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Original Article
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Korean J Obstet Gynecol. 2001;44(6):1056-1061. Published online June 1, 2001.
- Histologic Diagnosis of Cervcial Precursor Lesion: Applying the Bethesda System and HPV 16, 18 Correlates.
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Jong Lee, Mi Sook Kim, Chi Dong Han, Jeong Ja Park, Jae Bok Park, Tae Sung Lee
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1Department of Obstetrics and Gnecology, College of Medicine, Catholic University of Daegu.
2Department of Pathology, College of Medicine, Catholic University of Daegu.
- Abstract
- OBJECT: To support the application of the Bethesda classification to the histologic diagnosis of cervical squamous lesions. METHODS: We evaluated the cervical biopsies and human papilloma virus (HPV) DNA status of 100 clinic patients. The 100 biopsy specimens were analyzed using criteria of the Bethesda system for low-grade squamous intraepithelial lesion(LSIL) and high-grade squamous intraepithelial lesions(HSIL) in association with analysis of HPV DNA virus type by PCR. RESULTS: By PCR amplified from paraffin embedded tissues, the 40 of 90 cases of classified as HSIL were HPV 16 or 18 positive and 1/10 cases of classified as LSIL was HPV 16 positive. CONCLUSION: This study supports the usefullness of certain histologic criteria of the Bethesda system for distinguishing squamous intraepithelial lesions into two grades.
Keywords :Cervix;Human papillomavirus;PCR;The Bethesda System
