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Original Article
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Korean J Obstet Gynecol. 2011;54(1):26-36. Published online January 1, 2011.
DOI: https://doi.org/10.5468/KJOG.2011.54.1.26
- Maternal serum levels of C-reactive protein and placental levels of IL-6, lipid peroxide, and protein carbonyl in preterm birth according to histologic chorioamnionitis.
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Dae Seok Yoon, Yoon Ha Kim, Chul Hong Kim, Moon Kyoung Cho, Jong Woon Kim, Hye Yon Cho, Seok Mo Kim, Woo Dae Kang, Ki Ho Lee, Tae Bok Song
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1Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. kimyh@chonnam.ac.kr
2Department of Obstetrics and Gynecology, Seonam University College of Medicine, Namwon, Korea.
- Abstract
- OBJECTIVE
To evaluate predictive value of maternal serum white blood cells (WBCs), C-reactive protein (CRP) levels, placental interleukin-6 (IL-6), lipid peroxide, and protein carbonyl levels in preterm birth according to histologic chorioamnionitis (HCA). METHODS: This cohort study included 45 cases of preterm delivery with preterm labor and intact membranes (preterm labor [PTL] group; n=16) and preterm premature rupture of membranes (preterm premature rupture of membranes [PPROM] group; n=29). Blood samples at admission and placental sample at postpartum were collected. HCA was diagnosed in the presence of neutrophils infiltration into the subamnionic space. RESULTS: The incidence of HCA was significantly higher in PPROM group than PTL group. Maternal serum WBC and CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels in HCA group were significantly higher than group without HCA. Maternal serum CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels of PPROM group with HCA were significantly higher than PPROM group without HCA. Maternal serum CRP levels at admission of 7 days and more latency period (n=14) were significantly lowered than those of less than 7 days latency period (n=15). The cut-off points of CRP determined with the receiver operating characteristic curves was 0.875 mg/dL. Perinatal morbidity such as respiratory distress syndrome, intraventricular hemorrhage, pneumonia in HCA group was significantly higher than group without HCA. CONCLUSION: Maternal serum CRP on admission may be possible a predictor for duration of the latency period in PPROM.
Keywords :Preterm birth;Histologic chorioamnionitis;C-reactive protein;Lipid peroxides;Protein carbonyls