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DOI: https://doi.org/10.5468/ogs.22060    [Accepted]
Published online August 2, 2022.
COVID-19 and vaccination during pregnancy: a systematic analysis using Korea National Health Insurance claims data
Ki Hoon Ahn1, Hae-In Kim1,2,3, Kwang-Sig Lee3, Ju Sun Heo4, Ho-Yeon Kim1, Geum-Joon Cho1, Soon-Cheol Hong1, Min- Jeong Oh1, Hae-Joong Kim1
1Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea
2School of Industrial Management Engineering, Korea University, Seoul, Korea
3AI Center, Korea University Anam Hospital, Seoul, Korea
4Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
Correspondence:  Ki Hoon Ahn,
Email: akh1220@hanmail.net
Received: 12 February 2022   • Revised: 19 May 2022   • Accepted: 19 July 2022
Abstract
Objective
This study systematically analyzed coronavirus disease 2019 (COVID-19) and vaccination details during pregnancy by using the national health insurance claims data.
Methods
Population-based retrospective cohort data of 12,399,065 women aged 15-49 years were obtained from the Korea National Health Insurance Service claims database between 2019 and 2021. Univariate analysis was performed to compare the obstetric outcomes of pregnant women (ICD-10 O00-O94) and their newborns (ICD-10 P00-P96) with and without COVID-19. Univariate analysis was also performed to compare the age and obstetric outcomes of pregnant women receiving different types of vaccines.
Results
The percentage of pregnant women with COVID-19 during pregnancy was 0.11%. Some obstetric outcomes of pregnant women with COVID-19, including the rates of preterm birth or cesarean delivery, were significantly better than those of pregnant women without COVID-19. The rate of miscarriage was higher in pregnant women with COVID-19 than without COVID-19. However, the outcomes of newborns of women with and without COVID-19 were not significantly different. Regarding vaccination type, obstetric outcomes of pregnant women appeared to be worse with the viral vector vaccine than with the mRNA vaccine.
Conclusion
To the best of our knowledge, this is the first study to systematically analyze COVID-19 and vaccination details during pregnancy using the national health insurance claims data in Korea. The obstetric outcomes in pregnant women with and without COVID-19 and their newborns were similar.
Key Words: COVID-19, Vaccination, Pregnancy, Infant, newborn, Pregnancy outcome
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