A case of clear cell carcinoma of uterine cervix not related to intrauterine dietylstilbesterol exposure.

Jeon, Dong Su; Lee, Chae Hyeong; Park, Hyun Soo; Yoon, Sang Ho; Choi, Jong Sun; Kim, Eo Jin; Roh, Ju Won; Min, Eung Gi

doi:2010.53.4.371

Obstet Gynecol Sci > Volume 53(4); 2010 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2010;53(4):371-376.
DOI: https://doi.org/10.5468/kjog.2010.53.4.371 Published online April 1, 2010.

A case of clear cell carcinoma of uterine cervix not related to intrauterine dietylstilbesterol exposure.

Dong Su Jeon, Chae Hyeong Lee, Hyun Soo Park, Sang Ho Yoon, Jong Sun Choi, Eo Jin Kim, Ju Won Roh, Eung Gi Min

¹Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea. rohjuwon@dumc.or.kr
²Department of Pathology, Dongguk University Ilsan Hospital, Goyang, Korea.

Abstract

Clear cell carcinoma of the uterine cervix is rare cancer that accounts for 4 to 9% of the adenocarcinoma of uterine cervix. Although intrauterine exposure to diethylstilbestrol (DES) during early pregnancy is one of the established risk factors, DES exposure may not be confirmed in all patients. We experienced a case of clear cell carcinoma in the uterine cervix of 67-year-old woman who was not exposed to DES. She was initially diagnosed as endometrial clear cell carcinoma because of the normal colposcopic finding and histologically proven clear cell carcinoma from endometrial aspiration biopsy and endocervical curettage. We performed a total laparoscopic hysterectomy with bilateral salpingo-oophorectomy and lymphadnectomy including both pelvic and para-aortic regions. On the final pathologic diagnosis of clear cell carcinoma confined to endocervix, the patient was received adjuvant concurrent chemoradiation with weekly cisplatin. We present the case with a brief review of related literature.

Key Words: Clear cell carcinoma, Cervical carcinoma, Diethylstilbestrol