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Korean Journal of Obstetrics & Gynecology 2007;50(1):135-141.
Published online January 1, 2007.
Clinical value of serum vascular endothelial growth factor (VEGF) in ovarian diseases.
Joo Hee Yoon, Dae Hoon Kim, Young Oak Lew
Department of Obstetrics and Gynecology, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea. yolew@catholic.ac.kr
Abstract
OBJECTIVE
The aim of this study was to evaluate the concentration of serum VEGF and its relationship with the clinical parameters and the tumor markers in ovarian diseases. METHODS: We measured the serum VEGF concentrations by ELISA in 76 patients with benign ovarian disease, as well as 9 normal volunteers, 4 patients with ovarian borderline malignancy and 53 patients with ovarian cancer. RESULTS: There is a significant statistical difference between the serum VEGF levels in patients with benign ovarian disease (157.7+/-197.8 pg/ml) and ovarian cancer (344.7+/-372.2 pg/ml) (p<0.005). CONCLUSION: Serum VEGF may help in the differential diagnosis between benign and malignant ovarian disease. We suggest that serum VEGF may be useful as a diagnostic tool in ovarian disease.
Key Words: Ovarian disease, VEGF


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