Interleukin-10 Gene -592 Promoter Polymorphism in Patients with Endometriosis.

Hwang, Kyu Ri; Choi, Young Min; Kim, Jong Mee; Kim, Jin Ju; Park, Kyoung Ah; Ji, Byung Chul; Ku, Seung Yup; Suh, Chang Suk; Kim, Seok Hyun; Kim, Jung Gu; Moon, Shin Yong

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Original Article

Korean Journal of Obstetrics & Gynecology 2006;49(7):1501-1507.
Published online July 1, 2006.

Interleukin-10 Gene -592 Promoter Polymorphism in Patients with Endometriosis.

Kyu Ri Hwang, Young Min Choi, Jong Mee Kim, Jin Ju Kim, Kyoung Ah Park, Byung Chul Ji, Seung Yup Ku, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon

¹Department of Obstetrics and Gynecology, College of Medicine, Seoul National University College of Medicine, Korea. ymchoi@snu.ac.kr
²Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea.
³Health Care System Gangnam Center, Korea.
⁴Department of Obstetrics and Gynecology, Boramae Hospital, Seoul, Korea.

Abstract

OBJECTIVE
To explore the association of the interleukin-10 (IL-10) gene -592 promoter polymorphism with endometriosis in a Korean population. METHODS: This study comprised 254 women with surgically or histologically diagnosed endometriosis, 236 control women with no evidence of endometriosis by laparoscopy or laparotomy. Following extraction of genomic DNA, genotyping of the IL-10 gene -592 polymorphism was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The distribution of genotypes and allele frequencies of IL-10 gene -592 polymorphism in the endometriosis group did not differ from those in the control group (A/A: A/C: C/C, 41.3%: 51.2%: 7.5% vs. 44.9%: 50.8%: 4.2%). And when classified by stage, there was also no significant difference in the distribution of IL-10 gene -592 polymorphism between patients with stage I-II (ASRM, 1997) endometriosis or patients with stage III-IV endometriosis and controls. CONCLUSION: These results suggest that IL-10 gene -592 promoter polymorphism is not associated with the risk for endometriosis in the Korean women.

Key Words: Endometriosis, IL-10 gene, Polymorphism

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