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Korean Journal of Obstetrics & Gynecology 2005;48(5):1202-1210.
Published online May 1, 2005.
Changes in the Total Antioxidant Ability and Antioxidant Vitamin Levels in the Maternal Venous Plasma of Preeclampsia.
Young Mi Jeon, Jae Seok Yang, Young Jin Park, Yoon Ha Kim, Cheol Hong Kim, Mun Keong Jo, Ki Min Kim, Jong Woon Kim, Tae Bog Song, Bong Whan Ahn, Sung Yeul Yang
1Department of Obstetrics and Gynecology, Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.
2Department of Obstetrics and Gynecology, College of Medicine, Chonnam National University, Gwangju, Korea. kimyh@chonnam.ac.kr
3Department of Biochemistry, College of Medicine, Chonnam National University, Gwangju, Korea.
Abstract
OBJECTIVE
This study was aimed to compare lipid peroxide level, total peroxyl radical-trapping antioxidative parameter (TRAP) value, and antioxidant vitamin level in the maternal venous plasma between normal pregnancy and preeclampsia. METHODS: Samples of venous plasma were obtained from 38 normal and 24 preeclamptic women. Lipid peroxides levels were measured by thiobarbituric acid reaction. The TRAP values were measured by Wayner's method, although some reaction conditions were modified. Ascorbic acid, retinol, alpah-tocopherol, and gamma-tocopherol were measured by high performance liquid chromatography. RESULTS: There was no significant correlation between the lipid peroxides level in the maternal venous plasma and gestational age in normal pregnancy (n=38, r=0.04, p=NS). The lipid peroxide level in the maternal venous plasma of preeclampsia (n=24) was significantly higher than that of gestational age-matched normal pregnancy (n=26), (4.39 +/- 0.38 vs. 3.23 +/- 0.15 nmol/mg protein, p<0.01). There was no significant correlation between the TRAP value in the maternal venous plasma and gestational age in normal pregnancy (n=38, r=0.02, p=NS). The TRAP value in the maternal venous plasma of preeclampsia (n=24) was significantly lower than that of gestational age-matched normal pregnancy (n=26), (0.33 +/- 0.02 vs. 0.38 +/- 0.02 mM, p<0.05). Ascorbic acid level in the maternal venous plasma of preeclampsia was significantly lower than that of normal pregnancy (377.8 +/- 23.6 vs. 552.2 +/- 52.1 nmol/mL, p<0.05). However, there was no significant difference in maternal venous plasma retinol, alpah-tocopherol, and gamma-tocopherol levels between normal pregnancy and preeclampsia. CONCLUSION: The above results suggest that the imbalance of increased lipid peroxidation and decreased antioxidant activity were in the maternal blood of preeclampsia, and an antioxidant vitamin, ascorbic acid, may be decreased result from counteracting free radical-mediated cell disturbance.
Key Words: Preeclampsia, Oxidative stress, Antioxidants, Maternal venous plama


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