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Korean Journal of Obstetrics & Gynecology 2002;45(12):2273-2279.
Published online December 1, 2002.
Recombinant Human Follicle Stimulating Hormone (rFSH) versus Highly Purified Urinary FSH (uFSH): Oocyte and Embryo Quality.
Kuol Hur, Kang Woo Cheon, Hye Kyung Byun, Kwang Moon Yang, Jin Young Kim, In Ok Song, Keun Jai Yoo, Inn Soo Kang, Mi Kyoung Koong
1Division of Reproductive Endocrinology and Infertility, Laboratory of Reproductive Biology and infertility, Korea.
2Department of Obstetrics and Gynecology Samsung Cheil Hospital and Women's Health Care Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
To estimate the efficacy of recombinant human follicle stimulating hormone (rFSH) versus highly purified urinary human FSH (uFSH) in women undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization and embryo transfer (IVF-ET). METHODS: From 1 January 2001 to 31 August 2001, A total of 254 cycles from 241 patients who attended infertility clinic at Samsung cheil hospital was enrolled in this study. With pituitary down regulation using GnRH agonist by short protocol, rFSH (Puregon(R), Organon, Netherlands) was administered in 131 cycles and uFSH (Metrodin-HP(R), Serono, Switzerland) was administered in 123 cycles. We analyzed ovarian response, pregnancy rate, live birth rate, oocyte quality and embryo quality. RESULTS: The clinical characteristics of two groups were not different. Total FSH dosages (1322.3+/-526.2 IU versus 2124.4+/-881.9 IU, p<0.001) and dosages per retrieved oocyte (90.6+/-36.0 IU versus 138.0+/-57.2 IU, p<0.001) were significantly lower in rFSH group than uFSH group. Clinical pregnancy rate and live birth rate of two groups were not significantly different. The rate of good quality oocyte (Grade I and II) from retrieved oocytes was higher in rFSH group (68.2% versus 64.8%, p=0.024), but after preincubating oocytes for 4 to 6 hours and removing cumulus cells in intracytoplasmic sperm injection (ICSI) cycles, nuclear maturity of oocytes were not significantly different. The quality of transferred embryos were not significantly different too. CONCLUSION: rFSH offered more effective ovarian response in COH and better quality of retrieved oocytes, compared with uFSH.
Key Words: Recombinant human follicle stimulating hormone (rFSH), highly purified urinary human FSH (uFSH), controlled ovarian hyperstimulation (COH), oocyte quality, embryo quality


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