Poorly Differentiated Endometrial Adenocarcinoma with Trophoblastic Differentiation.

Song, Hyun Jung; Shim, Sung Shin; Han, Woon Sup; Kim, Seung Cheol

Case Report

Korean Journal of Obstetrics & Gynecology 2002;45(5):888-893.
Published online May 1, 2002.

Poorly Differentiated Endometrial Adenocarcinoma with Trophoblastic Differentiation.

Hyun Jung Song, Sung Shin Shim, Woon Sup Han, Seung Cheol Kim

¹Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, Korea.
²Department of Pathology, Ewha Womans University College of Medicine, Seoul, Korea.

Abstract

Trophoblastic differentiation in gynecologic nontrophoblastic tumor is very rare. Here we present a 66-year-old female with poorly differentiated endometrial carcinoma showing trophoblast-like differentiation. This tumor was in advanced stage with metastases to lung, liver, and bone at diagnosis. The multinucleated, syncytiotrophoblast-like cells were positive for beta-human chorionic gonadotropin (beta-hCG) by immunochemical stain. The level of beta-hCG was also elevated (219 mIU/ml) in the patient's serum, but dropped after surgery and chemotherapy. beta-hCG may be used as tumor marker in this case.

Key Words: Endometrial adenocarcinoma, Trophoblastic differentiation, tumor marker, beta-hCG