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Korean Journal of Obstetrics & Gynecology 2002;45(5):888-893.
Published online May 1, 2002.
Poorly Differentiated Endometrial Adenocarcinoma with Trophoblastic Differentiation.
Hyun Jung Song, Sung Shin Shim, Woon Sup Han, Seung Cheol Kim
1Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, Korea.
2Department of Pathology, Ewha Womans University College of Medicine, Seoul, Korea.
Abstract
Trophoblastic differentiation in gynecologic nontrophoblastic tumor is very rare. Here we present a 66-year-old female with poorly differentiated endometrial carcinoma showing trophoblast-like differentiation. This tumor was in advanced stage with metastases to lung, liver, and bone at diagnosis. The multinucleated, syncytiotrophoblast-like cells were positive for beta-human chorionic gonadotropin (beta-hCG) by immunochemical stain. The level of beta-hCG was also elevated (219 mIU/ml) in the patient's serum, but dropped after surgery and chemotherapy. beta-hCG may be used as tumor marker in this case.
Key Words: Endometrial adenocarcinoma, Trophoblastic differentiation, tumor marker, beta-hCG


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